Cheng Liang's team from Soochow University and Professor Dong Zhiqiang of Huazhong Agricultural University AS: Titanium sulfide nanosheets are used as cascaded bioreactors for gas-sonic dynamic combination therapy of cancer

Innovation: Titanium sulfide nanosheets (TiS_X NS s)

Keywords: titanium sulfide nanosheets, nano cascade reactors, hydrogen sulfide, gas therapy, acoustic dynamic therapy

Acoustic dynamic therapy (SDT) is a new type of medical treatment, mainly in the presence of voice sensitizers, through local ultrasound to produce a large number of reactive oxygen species (ROS) to play a good killing effect, because of its high tissue penetration depth, good aggregation specificity and negligible side effects and other characteristics have been widely concerned

Gas therapy (GT) can use a certain gas to regulate the course of the disease and has become a promising tumor treatment strategy

Recently, Professor Cheng Liang's team from Soochow University and Professor Dong Zhiqiang of Huazhong Agricultural University have developed a transition metal sulfide-based nanoscale reactor - titanium sulfide nanosheet (TiS _X NS_s), which can release a large amount of H2_{without any H2}S donor due to the presence_{of sulfur} S gas, for GT and immunomodulation, with the release of_H2S, TiS_X NS_s surface formed a large number of S vacancies and partial oxidation to form TiO_X, thus giving TiS_X NS_s a new sonic dynamic effect for tumor SDT, This results in a programmed GT-SDT of the tumor, which further enhances the therapeutic effect of the tumor (Figure 1

Figure 1.

At the cellular and animal levels, TiS_{X NSs} showed good tumor killing effect and, through immune regulation of the body, inhibited the metastasis and recurrence of tumors, prolonging its survival.

WILEY

Thesis Information:

Titanium Sulfide Nanosheets Serve as Cascade Bioreactors for H2S-Mediated Programmed Gas–Sonodynamic Cancer Therapy,

Guangqiang Li, Huali Lei, Yuqi Yang, Xiaoyan Zhong*, Fei Gong, Yuehan Gong, Yangkai Zhou, Yuqi Zhang, Haibin Shi, Zhidong Xiao, Zhiqiang Dong*, and Liang Cheng*,

Advanced Science

DOI: 10.

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