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Editor in charge: Food Science
Original title: Chen Yihua's research group from Institute of Microbiology, Chinese Academy of Sciences published a review on heptose-containing microbial natural product drugs in NPR
Sugar plays a pivotal role in life activities.
As an important component of bacterial lipopolysaccharide LPS, heptose is essential for the cell wall composition of gram-negative bacteria, bacterial infection and foodmate.
Septacidin is a secondary metabolite produced by gram-positive bacteria.
In 2020, the research team proved that the N6-glycosylated adenine structure of heptosecide was formed by the special Fe(II)-dependent glycosyltransferase SepE, and also proved that SepF is a novel glycosidase that can be hydrolyzed The CN glycosidic bond of the heptosidin precursor compound generates intermediate SEP-328.
Recently, the research group was invited by the authoritative review journal "Natural Products Reports" to write a review "Heptose-co"Ntaining bacterial natural products: structures, bioactivities, and biosyntheses" was published online.
Changes in glycosyl units can significantly affect the pharmacological properties of natural products.
Regarding the analysis of the formation mechanism of N6-glycosylated adenine in heptosecide, Dr.
(This article is reprinted by "Food Science Network", and the article is from the WeChat account of the Institute of Microbiology, Chinese Academy of Sciences.
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