Chem: a simpler way to prepare drugs

October 20, 2019 / biourn / - recently, organic chemists from Ohio State University have figured out how to synthesize the most common molecular structure in medicine This scientific discovery can change the way many drugs are produced, including one of the most commonly used drugs to treat ovarian cancer Their findings, published today in the journal Chem, provide new drug manufacturing processes for drug manufacturers Up to now, these drugs are made by complex process, which leads to a lot of waste David Nagib, senior author of the study and assistant professor of chemistry and biochemistry at Ohio State University, said the new discovery could allow drug makers to complete basic drug design in one step Drug molecules must interact with molecules in the body in the right way to work It's like when two people meet: everyone has to shake hands with their right hands If one tries to use his left hand, it will not work The most common molecular arrangement used in drugs is based on their effective interaction with human molecules, known as "chiral piperidine." At present, the synthesis of this molecular structure by drug manufacturers involves a lot of waste, about half of which are thrown away because of the wrong conformation (image source: www Pixabay Com) zusiao Zhang, a postdoctoral researcher at Nagib laboratory, the lead author of the study, said: "before, there was no simple way to simply exchange a single hydrocarbon bond for a carbon carbon bond We have found that we can achieve this through free radicals " The core of their discovery is the chemical bonds that make up the molecules The researchers studied how many drug molecules are produced One is the use of chiral piperidine in the anticancer drug nilapaprib, a drug used to treat ovarian cancer But to make it, drug manufacturers must make many symmetrical mixtures, and then peel off parts until they reach the asymmetric molecules necessary to make the drug effective The synthesis of the hexahedral ring has been a problem for chemists for decades In fact, this is so tricky that when Zhang first proposed a solution to Nagib, Nagib was not sure if it was right "The success of this chemical method is entirely due to zusiao's courage and ambition to solve this problem," Nagib said Nagib hopes this approach will make many drugs easier to produce Source of information: a simple way to make some medicines original source: zuxiao Zhang, Xin Zhang, David A Nagib Central pipelines from acylic amines via energetic selective, radical medicated δ C – h circulation Chem, 2019; doi: 10.1016/j.champr.2019.09.010