Characteristic table of NFPA prolactin elevated patients

Ref: Park SS, et alWorld Neurosurg2018 Nov;119:e1035-e1040doi: 10.1016/j.wneu.2018.08.068Epub 2018 Aug 23.:developed hyperlactinemia in patients with non-functional pituitary adenomas (nonfunction pituitary adenomas), which is believed to be caused by large adenomas that compress the pituitary shankHowever, not all large NFPAs cause elevated serum prolactinSeung Shin Park, department of internal medicine at Seoul National University School of Medicine in South Korea, and others analyzing clinical manifestations and imaging characteristics of different prolactin levels in large NFPAs patients are published online in World Neurology in August 2018the authors studied NFPA patients who had underwent butterfly surgery at Seoul National Hospital between 2010 and 2017All operations are performed by the same doctorMeasure the before and after (AP), width and maximum diameter of the NFPA on MRI imaging and calculate the volumeMorning basic hormones and dynamic tests were measured before and after surgery 3 monthsHyperlactinemia is defined as serollin levels of more than 20 ng/mL in men and 25 ng/mL in womenComparing the different characteristics of clinical and imaging performance in patients with high prolactin hemorrhage of NFPA with those with normal prolactinincluded a total of 201 NFAP patients, of which 101 (50.7%) were male, with an average age of 51.1 years and a BMI average of 25.5 kg/m2The average value of tumor AP, high and wide maximum diameter was 22.6 to 7.0mm, 30.3 to 7.7mm and 26.8 to 6.3mm, respectively, and the average tumor volume was 10.4 to 7.7cm3, all of which belonged to large adenomas98 (49.0%) tumors attacked sinuses Of the 201 patients , 59 (29.4%) had hyperlactinemia prior to surgery The proportion of women with hyperlactinemia is higher than that of those with normal prolactin Patients with hyperlactinemia are younger than normal prolactin patients The prevalence of preoperative TSH and gonadotropin deficiency in patients with hyperlactinemia was higher than in those with normal prolactin In patients with normal pituitary adenoma with preoperative prolactinemia, 1 case (0.7%) developed hyperprolemia after surgery, and 4 cases (6.9%) of patients with preoperative hyperlactin emias were still high High lactinemia is not associated with the occurrence of postoperative uremia After adjusting age, sex, body mass index, tumor volume and total excision rate, it was found that the postoperative hormone recovery rate of patients with hyperlactinemia was higher than that of those with preoperative prolactin (OR 2.55; 95% CI, 1.10, 5.92) The tumor margin and AP diameter ratio of patients with high prolactin emiaNFPA was higher than that of patients with normal prolactin NFPA, which was positively correlated with prolactin levels (r?0.186, P-0.008); authors believe that NFPA patients with hyperlactinemia have a higher tumor diameter-to-AP ratio, and that NFPA-induced hyperlactinemia may be affected by tumor growth patterns, rather than the tumor volume itself Preoperative lactin level is an indicator of postoperative hormone recovery, and patients with higher prolactin NFPA have better surgical efficacy.