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PHARD, Feb. 2 (Xinhua) -- People with enlarged gaps around cerebrovascular vessels may be more likely than others to develop cognitive problems or develop Alzheimer's disease over time, according to a study published online in the American Journal of Neurology.
findings may help in the early diagnosis of Alzheimer's disease.
the gap around the cerebrovascular vessels is a fluid-filled space around small blood vessels in the brain that is involved in the removal of waste and toxins in the brain, and the size of the gap may be associated with changes in the brain caused by aging.
at the University of New South Wales and others in Australia used eight years to track 414 people aged 72 to 92.
the elderly passed cognitive tests at the start of the study and every two years thereafter, undertaxed an Alzheimer's assessment, and undertaxed an MRI brain scan.
study, a total of 97 people were diagnosed with Alzheimer's disease.
31 of the 31 people who had the greatest gap around the cerebrovascular vessels were diagnosed with Alzheimer's disease.
researchers found that people with the largest gaps around the cerebrovascular vessels were nearly three times more likely to develop Alzheimer's disease than those with less or no larger gaps.
who experienced the greatest increase in the gap around the cerebrovascular vessels were also more likely to have a decrease in total cognitive impairment than those with less or no increase in clearance.
researchers point out that enlarged gaps around cerebrovascular vessels may mean impaired brain ability to remove waste, or may be a sign of cognitive decline or an increased risk of Alzheimer's disease, and more research is needed in the future to understand how these enlarged gaps around cerebrovascular vessels develop.