Changes in antioxidant, cell protection and whitening functions of pear fruits at different growth stages

On September 30, 2022, Professor Bai Hongjin's team from the School of Chemistry and Chemical Engineering of Tarim University and Professor Shen Lirong of Zhejiang University published a paper entitled "Antioxidative, cytoprotective and whitening activities of fragrant pear fruits at different" in the international journal Frontiers in Nutrition (Q1, IF: 6.
590).
Growth Stages", authors: Jiang Hui, Tong Fei, Jiang Xi, Pu Yunfeng, Shen Lirong, Wu Cuiyun*, Bai ^Hongjin*
.
The research was supported
by the Southern Xinjiang Key Industry Innovation and Development Support Program (2017DB006) and the Tarim University Graduate Research and Innovation Program (TDGRI202003).

With the continuous development of social economy and the continuous improvement of people's quality of life, the health care effect of fruits has gradually become the focus
of people's attention.
In China, pears are the third most consumed fruit after apples and citrus, and have been praised
by consumers for their crispy, sweet and juicy mouth.
Pear fruit is rich in protein, crude fiber, sugar, calcium, iron, phosphorus, vitamins and polyphenols, which have the effects
of nourishing yin and clearing heat, lowering blood pressure and so on.
The phenolic compounds in pear fruit are pure natural antioxidants, the main components of which are flavonoids
.
In the process of growth and development of pears, a series of physiological and biochemical changes occur with ripening of the fruits, but up to now, there are few
systematic studies on the metabolism and biological activities of phenolic compounds in fruits at different growth periods of Xinjiang pear fruits 。 The research group selected Xinjiang real estate Nanguo pear, Aksu sentence pear, red fragrant pear and Luntai sentence pear as the research objects, used HPLC method to investigate the changes of phenolic compound content in fruits in different growth periods, and established a model of HEK-293 cell damage induced by oxidative stress, constructed a cell model of high melanin expression induced by α-MSH, revealed the protective effect of pear fruit extract on HEK-293 cells and the inhibitory effect on melanin production in B16 cells, and preliminarily explored its mechanism of action , in order to provide a scientific basis
for the application of pear fruit extract in cosmetics or medicines.

·Research Highlights·

Through statistics, principal component analysis and correlation discriminant analysis, the metabolic process of phenolic compounds in pear fruits at different growth periods was systematically studied.

Based on the HEK-293 cell damage model induced by oxidative stress and the construction of α-MSH-induced melanin high expression cell model, the health care activity of pear fruit extract in different growth periods was comprehensively evaluated, which provided a scientific reference
for the deep processing of pear products.

·Research Conclusion·

The content of phenolic compounds in pear fruits at different growth periods has significant differences, that is, with the continuous ripening of fruits, the content of phenolic compounds in fruits is gradually decreasing
.

Four kinds of pear fruit extracts showed good antioxidant activity, cytoprotective activity and whitening activity, among which the biological activity of Nanguo pear was the best
.

The antioxidant activity, cytoprotective activity and whitening activity of pear fruit at different growth stages also had significant differences, among which the biological activity of pear fruit extract was the best at the
young fruit stage.

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