CFDA approves the listing of highly selective central antiemetic arepidem

Chemotherapy is an important treatment for many cancer patients Nausea and vomiting (CINV) caused by chemotherapy is the most common adverse reactions, which may lead to metabolic disorders, damage to the body function, and even make patients refuse to further chemotherapy, which seriously affects the quality of life and the effect of anti-tumor treatment According to the survey, more than 75% of chemotherapy drugs will cause CINV China's State Food and drug administration has approved the world's first highly selective NK-1 receptor antagonist, aripitan, for clinical use in China So far, the drug has been registered and approved in more than 90 countries around the world, with more than 10 million users of chemotherapy courses Studies have shown that CINV is regulated by two key pathways, one is the central brain pathway and the other is the peripheral gastrointestinal pathway Substance P is a neurokinin located in neurons of central and peripheral nervous system It plays a role through NK-1 receptor, and is related to many kinds of inflammatory immune reactions such as vomiting and pain Arepidem is an antagonist of NK-1 receptor, which can cross the blood-brain barrier, bind to NK-1 receptor in brain with high selectivity and affinity, and antagonize substance P, so as to inhibit the source of CINV in chemotherapy at central level and effectively control the delayed CINV The American Society of Clinical Oncology (ASCO) and the National Cancer Network clinical application guide (NCCN) have taken arepidem as the first-line drug and recommended drug for the prevention of CINV Prof Wu Yilong's speech at the listing meeting of the United States of America, MSD China announced in Guangzhou that its drug for preventing nausea and vomiting caused by chemotherapy, i.e (aripitan capsule), has been approved by the State Food and Drug Administration of China to be listed in China Experts attending the meeting believe that as the first highly selective NK-1 receptor antagonist in the world that has been on the market for ten years in foreign countries, it is expected to improve the treatment compliance and quality of life for the vast number of Chinese chemotherapy patients Cancer has become the second fatal disease in China, and for many patients receiving chemotherapy, nausea and vomiting are accompanied by nightmares Professor Wu Yilong, chairman of clinical tumor cooperation center of China Anti Cancer Association and vice president of Guangdong People's Hospital and director of Guangdong Lung Cancer Research Institute, said: "nausea and vomiting caused by chemotherapy are the most common adverse reactions of chemotherapy, which may lead to metabolic disorder, impairment of body function, malnutrition, delayed wound healing, and even make patients refuse further chemotherapy The quality of life and the effect of anti-tumor treatment How to solve this problem and provide guarantee for the smooth progress of tumor treatment is an urgent medical demand At today's conference, the latest 2014 tumor therapy related vomiting prevention and treatment guidelines was also released This new version of the guidelines recommends that the "triple plan" - aripitan, 5-HT receptor antagonists, combined with dexamethasone, be used as the first-line treatment plan of chemotherapy to stop vomiting at present Starting from the "dual channel" of the central and gastrointestinal tract, the nausea and vomiting caused by chemotherapy can be comprehensively solved to make patients feel at ease At the scene, hundreds of experts and media reporters also launched the public welfare initiative of "refuse to vomit, have a good heart", calling on clinicians, media, patients, family members and the public to work together to care for chemotherapy patients, pay attention to their treatment needs, standardize the prevention of chemotherapy adverse reactions, so as to improve the survival and treatment quality of patients More than 75% of chemotherapy drugs will lead to nausea and vomiting Piano teacher Luo min (pseudonym) was unfortunately diagnosed with breast cancer From the moment she got the diagnosis sheet, she and her family chose to fight with the disease However, repeated nausea and vomiting caused by chemotherapy made her sleepless and miserable Helplessness and fear, helplessness and sadness, devoured the happy home and good life Now, as soon as she entered the hospital gate, she could not help but start retching "Chemotherapy may save my life, but I've lost my life What should I do?" she asked According to the world cancer report released by the World Health Organization, in 2012, the number of new cancer cases and deaths in the world increased significantly, with China bearing the brunt: About 3.07 million new cancer cases in China, accounting for 21.9% of the global total; about 2.2 million cancer deaths, accounting for 26.8% of the global cancer deaths "There is a kind of nausea and vomiting in the world that is gratifying, that is, the pregnant wife tells her husband that she is happy; there is also a kind of nausea and vomiting that is hopeless, which is caused by cancer chemotherapy, and needs high attention from medical staff." Professor Pan Hongming, vice president of Shao Yifu Hospital Affiliated to Zhejiang University and director of oncology department, said at the meeting Chemotherapy is an important treatment for many cancer patients However, with chemotherapy, it is alopecia, nausea, vomiting and other adverse reactions According to the research, more than 75% of chemotherapy drugs will lead to nausea and vomiting, and the pain brought by chemotherapy will often make patients flinch from continuing treatment, some even lose their confidence in life and give up the opportunity of treatment Professor Xu Ruihua, vice president of Cancer Hospital of Sun Yat sen University and executive director of China Anti Cancer Association, stressed: "the prevention and treatment of such adverse reactions is very important, and its importance is no less than the chemotherapy scheme itself." New drugs help chemotherapy patients: refuse to vomit, and reassuring treatment experts vividly explain that the nausea and vomiting caused by chemotherapy (CINV) are regulated by two key pathways: one is the central (brain) pathway, the other is the peripheral (gastrointestinal) pathway Acute CINV refers to the reaction within 0-24 hours after chemotherapy, which is mainly controlled by peripheral (gastrointestinal) pathway; delayed CINV occurs within 24-120 hours after chemotherapy, which is mainly controlled by central pathway In the current clinical treatment, although there are many drugs that can inhibit the acute response, they still need drugs that can effectively act on the central pathway to control the delayed nausea and vomiting Professor Xu Ruihua said: "the new drug, Yimei? (aripitan capsule), filled the gap It is the first highly selective NK-1 receptor antagonist in the world It can cross the blood-brain barrier and occupy the NK-1 receptor in the brain with high selectivity and affinity, so as to inhibit the source of CINV at the central level It can be used to prevent acute and delayed nausea and vomiting during the initial and repeated treatment of highly emetic antineoplastic chemotherapy " At present, Yimei? (aripitan capsule) has been registered and approved in more than 90 countries around the world It has been used for more than 10 million chemotherapy courses around the world, helping cancer patients to alleviate nausea and vomiting caused by chemotherapy From the first day, it has been treated with ease and improved the quality of life of cancer patients As a first-line drug and recommended drug for the prevention of nausea and vomiting caused by high emetic anti-tumor chemotherapy, the new version of China's guidelines for the prevention and treatment of vomiting related to cancer treatment was released Arepidem was unanimously recommended by the NCCN and other European and American authoritative guidelines At today's meeting, the 2014 version of China's guidelines for the prevention and treatment of vomiting related to cancer treatment was officially released The guide emphasizes the importance of preventing nausea and vomiting caused by chemotherapy to patients and the implementation of chemotherapy program, expounds the types, causes and treatment principles of nausea and vomiting caused by chemotherapy, introduces the mechanism and usage of NK-1 receptor antagonist antiemetic drugs, and gives the emetic classification and prevention methods of anti-tumor drugs The guidelines clearly recommend the use of a combination of 5-HT3 receptor antagonist, dexamethasone and NK-1 receptor antagonist to prevent nausea and vomiting caused by highly emetic chemotherapy Professor Pan Hongming, vice president of Shao Yifu Hospital Affiliated to Zhejiang University and director of oncology department, said that Yimei (aripitan capsule) will bring renewal and better choice for clinical medication, improve the compliance of patients with treatment, and then better achieve the treatment effect This is a powerful weapon for clinicians to help patients prevent nausea and vomiting caused by chemotherapy, and it also illuminates the anti-cancer road of cancer chemotherapy patients in China Professor Hu Xichun, deputy director of chemotherapy Department of Fudan University Cancer Hospital, believes that the goal of clinicians is to make patients accept a more effective, standardized and standardized program "At present, clinical data at home and abroad show that the overall safety of this new drug is very good, and elderly cancer chemotherapy patients can also use it." Experts and media reporters at the meeting launched a public welfare initiative called "fight against vomiting, have a good heart" Experts and media care for patients: fight against vomiting, have a good heart in China, and thousands of cancer patients are undergoing or waiting for chemotherapy At the meeting, hundreds of experts, doctors, and media reporters joined the public welfare initiative of "overcoming vomiting and having a good heart" in the form of wish cards, microblogs, wechat, etc., hoping that patients would not suffer from the pain of nausea and vomiting caused by chemotherapy and would be relieved to receive treatment On the conference board, a doctor wrote: "it's just as important to extend the life of patients as to improve the quality of life It's our duty to help patients prevent side effects." "I've been waiting for this new drug for ten years, and I'm waiting for it," said the expert Another patient left a message saying, "because I don't vomit, I'm willing to receive systemic chemotherapy." "The way we help patients is to try to spread the right knowledge of disease and educate the public," a media reporter wrote Another reporter said: "we feel the same, we bless together - Science and love can help patients overcome the disease!"