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Centrioles are a cylindrical structure that participates in the production of microtubules in cells.
Microtubules are fibers in cells that form a network, provide structure and shape for cells, and regulate transportation
.
In addition, centrioles need to form cilia, which are hair-like extensions on the cell surface, allowing the cells to receive and respond to signals from the outside
Researchers at the IRB Barcelona Microtubule Tissue Laboratory, led by Dr.
Jens Lüders, discovered a new key role of γTuRC as a centriole stabilizer and discovered a microcephaly.
In this type of microcephaly, γTuRC’s This new feature may have been disrupted
.
It is well known that γTuRC is related to centrioles and acts as the initiator of microtubule formation, but the role of this new stabilizer is currently unclear
Given that microtubules are vital to cell function, it is not surprising that their malfunctions are associated with a wide range of human diseases
.
"Our findings indicate that pathologies related to γTuRC defects or their localization, such as certain forms of adolescent scoliosis, eye diseases, and male infertility, may involve not only defects in microtubule production, but also defects in centriole stability
Reveal the γTuRC complex
γTuRC is a protein complex discovered 25 years ago
.
It has attracted widespread attention due to its key role in the formation of microtubules .
First author Dr.
Nina Schweizer, former IRB Barcelona postdoctoral researcher, said: "We must combine functional analysis with extended and super-resolution microscopy in human cell culture to locate γTuRC in the centriole cylinder and observe how it is.
As a centrioles stabilizer, independent of its role in the generation of microtubules
.
"
Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold