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▎Editor of WuXi AppTec content team
Why is Alzheimer's disease less friendly to women? If the reasons behind it can be found, then it is possible to find better ways to protect women and reduce the burden of
In response to these problems, a new paper published in the top academic journal "Cell" found that a gene on the X chromosome may explain the sex difference in
In the study, researchers at Case Western Reserve University found that the USP11 enzyme was expressed more
▲Research schematic (Image source: Reference [1])
Specifically, for cells to eliminate excess tau proteins, they need to add a chemical tag called ubiquitin to the tau protein, and the USPase system can regulate the addition or removal
Using a mouse model of the pathologically tau protein expressed in the brain to mimic the development of Alzheimer's disease, the researchers found that eliminating USP11 reduced tau protein accumulation in the brains of female mice, and this change further protected female mice from reducing the effects of
Although mouse models may not be able to fully replicate the pathological changes of tau seen in the human brain, the researchers also found that in the brains of female Alzheimer's patients, the intensity of USP11 was significantly positively correlated
The researchers said that drugs could theoretically be developed to inhibit the action of the USP11 enzyme, which will also be the focus of
[1] Yan et al.
, X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women, Cell (2022), https://doi.
org/10.
1016/j.
cell.
2022.
09.
002 [2] Why women may be more susceptible to Alzheimer’s disease.
Retrieved Oct.
8, 2022 from
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