Cells: What happens when stress comes into being fat...

Modern life is full of stress, and we know that long-term stress is not conducive to physical and mental healthRecently, scientists from Yale University figured out why stress causes inflammation in the body, and the culprit behind this is fat! The study was published online this week in the leading academic journal Cella long time ago, scientists knew that mental stress can damage health"Clinically, we know that 'stress yondyness' can make inflammatory diseases worse." Professor Andrew Wang, who led the study, saidHowever, this phenomenon is difficult to understandthis is because in stressful situations, hormones such as cortisol and epinephrine are secretedHowever, these hormones themselves weaken the inflammatory responseSo why does the inflammatory response become more severe under heavy pressure?scientists have found that in stressful environments, a cytokine called IL-6 appears to make inflammation worseIn mouse models, when scientists pump edified the animals and artificially put pressure on them, they would have an increase in IL-6 levels in their bloodIn the human body, IL-6 is known to induce a range ofautoimmunediseases, where did the IL-6, which came under these pressures, come from? To answer this question, the researchers made further explorations, and the answer was quite unexpected: These IL-6 molecules are actually secreted by brown fat cells!, brown fat cells generally play an important role in energy metabolism and regulating body temperature, and the "calorie-burning" work is associated with this type of adipose tissueAre they also related to stress?follow-up experiments confirm this hypothesis If the associated signaling pathways are suppressed and fat cells are not allowed to perceive the pressure of the brain, the inflammatory response will no longer worsen , the researchers also gave their explanations for the phenomenon They believe that under sudden stress, the body induces brown adipose tissue to release IL-6, which in turn promotes liver sugar and raises blood sugar In this way, whether the animal decides to "fight" or "escape" will have plenty of energy IL-6 from brown fat tissue peaks after the release of hormones such as cortisol and epinephrine This may also explain why these hormones inhibit the inflammatory response, but the inflammatory symptoms in the body still worsen researchers also found that by suppressing IL-6 with drugs, they could not only inhibit the inflammatory response of mice, but also make them less likely to be agitated in stressful environments The findings also suggest that some current drugs against IL-6 are expected to be used to treat some mental illnesses The researchers also initially observed that these drugs could relieve some of the symptoms of depression summary, when stress is transmitted to fat, it prompts the latter to secrete the molecule IL-6 Although this molecule helps to produce energy, it also has consequences such as inflammation In today's society, stress and fat are two things that people can't avoid The study links stress and fat and shows how we can avoid the side effects of the combination (
Biovalley Bioon.com)