Cell: Training Immunity - An Effective Way to Reduce SARS-CoV-2 Susceptibility!

May 12, 2020 /
PRNewswire
BIOON/-COVID-19 Is the worst global health crisis since the Spanish flu in 1918 and possibly the most important since the end of World War IICOVID-19 has infected millions of people and killed hundreds of thousandsThis requires not only the rapid mobilization of medical institutions and the medical community, but also the work of the entire medical community and the scientific community to determine the best ways to diagnose, prevent and treat patientsan important component of COVID-19 pathophysiology is the imbalance of inflammatory responses, and researchers from the University of Ladberg and the University of Bonn recently described an overview of these processes from this perspective and proposed a basic principle based on host-oriented therapy based on induction of training immune in high-risk populationsWith regard to SARS-CoV-2 infection, there are several very important issues that need to be urgently addressedimage source: Cellfirst, should work together to decipher the detailed pathophysiology of the diseaseWhile there are some similarities between this phase and other severe respiratory virus infections (e.ginfluenza), which helps us to propose the first immunomodulators for testing (e.ganakinra or tocilizumab), there are important differences that are likely to involve other pathwayssecond,, a detailed understanding of the pathophysiology of the disease will eventually lead to better design of new training immunological methods, requiring a lot of research to demonstrate the clinicalbenefits of the disease and identify the people with the highest medical benefitsfinally, clinical trials have begun in some countries to test the ability of card-mediated seedlings to prevent COVID-19However, cacao may not be the only vaccine with this positive xenosotic effect: new recombinant tuberculosis vaccines such as VPM1002, 12 or other vaccines such as measles vaccines and OPV may have similar effects and are also being considered for use in clinical trials This method of vaccination using training immunization, even if successful, provides partial protection only for a limited period of time Thus, training immunization is useful, but it is only a bridge to the development of a specific vaccine against SARS-CoV-2, the most important tool for controlling pandemics However, training for immune-enhanced host defenses, even effectively, may last only time and may help reduce the spread of infection in the first phase of the pandemic and is an important tool for combating the rapid spread of emerging pathogens another important aspect, the collaboration between all scientists and doctors in the COVID19 study should be emphasized In a crisis as severe as the SARS-CoV-2 pandemic, full communication methodologies and experimental processes, as well as collaboration in clinical trial , are critical to increasing the opportunities for finding new tools for diagnostic and treatments and to improving outcomes for our patients (biovalleybioon.com) Reference: MihaiG.Neteaetal.
Slingifimmunity: atoolfordalyinglyandandraseofSARS-CoV2infection.cell
DOI: 10.1016/j.cell.2020.04.042