CELL: TBL1XR1 mutation drives the occurrence of extra-end node lymphoma?
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Last Update: 2020-07-13
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Source: Internet
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Author: User
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The most aggressive B-cellslymphomaoften manifest themselves as body cell mutations that are present in vitro distribution and carry the TBL1XR1 gene, which are not characterized ablyrecently, researchers showed that the TBL1XR1 mutation tends toimmunereactions in body fluids toward the production of abnormal immature memory B cells (MB) while impairing plasma cell differentiationat the molecular level, the TBL1XR1 mutant works with the SMRT/HDAC3 inhibitor complex, combining MB cell transcription factor (TF) BACH2, while sacrificing the reproductive center (GC) transcription factor BCL6, resulting in pre-memory transcription reprogramming and cell destiny deviationantigen recovery, TBL1XR1 mutant MB cells cannot differentiate into plasma cells, but prioritize re-entry into new GC reactions, providing evidence for the mechanism of cyclic re-entry into lymphatic occurrenceeventually, the change in TBL1XR1 led to an amazing epigenetic immune cell lymphoma phenotype that mimicked human diseaseand mouse lymphoma have expanded MB-like cell populations that are consistent with the origin of MB cells and reveal unforeseen pathways to malignant transformation of the immune system
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