Cell: Surprise! Oral microbes hide treatment for intestinal diseases!

, July 9, 2020 /
/bio-valley-
--Although many people delay going to the dentist regularly, recent research suggests that the consequences of doing so may extend beyond tooth decay and root canalsFrom heart disease todiabetes, poor oral health is often a reflection of a person's overall health and may even be the cause of systemic diseasea collaborative study from the University of Michigan School of Medicine and the School of Dentistry, inflammatory bowel disease (IBD may be the latest development in the deterioration of the condition due to poor oral health, including Crohn's disease and ulcerative colitis, which affects about 3 million adults in the United StatesDrNobuhiko Kamada, an assistant professor of gastroenterology, has been studying gut microbes -- a collection of bacteria that are common in the gut -- for yearsHe notes a new link in the literature that is related to the overgrowth of bacteria coming from the inside and outside the intestines to theof IBDbacteria commonly found in the mouth"I decided to go to dental school and ask a question, does oral disease affect the severity of gastrointestinal disease?" said Kamadapicture source: A new mouse study by Wikipedia, published in the journal Cell, suggests that oralbacteriacan worsen intestinal inflammation in two ways in the first route, periodontitis causes an imbalance in the normal and healthy microbiome in the mouth, leading to an increase in bacteria that cause inflammation These disease-causing bacteria and then enter the intestines However, this alone may not be enough to trigger inflammation of the intestines By looking at changes in the microbiome in mice with colon inflammation, the team demonstrated that the oral bacteria may exacerbate inflammation in the intestines "The normal gut microbiome is resistant to the location of foreign or foreign bacteria," said Kamada, However, in mice with IBD, healthy gut bacteria are destroyed, impairing their ability to resist oral disease-causing bacteria "The team found that mice with inflammation of the mouth and intestines lost significantly more weight and increased disease activity in the second proposed pathway, periodontitis activates the immune system T cells in the mouth These oral T-cells also enter the intestines, exacerbating inflammation The normal microbiome of the gut is balanced by inflammation and regulating the activity of T-cells, which are fine-tuned to withstand the presence of bacteria However, Kamada says, inflammation in the mouth mainly produces inflammatory T cells that migrate to the intestines and are removed from the normal environment, eventually triggering an immune response in the intestines that worsens the disease this deterioration of intestinal inflammation is driven by the migration of oral organisms to the patient's intestines, highlighting the need to promote oral health as part of measures to promote overall health and well-being this study is meaningful for new treatments for IBD, because too many patients are still unable to use medication, leading to a decline in quality of life and eventual surgery, and this study importantly suggests that clinical outcomes of IBD may improve by monitoring oral inflammation -- an interesting concept (BioValleyBioon.com) References: cure for IBD be inside your mouth? "
The intermucosal connection between the mouth and gut in commensal pathobiont-driven colitis ," Cell, DOI: 10.1016/j.cell.2020.05.048