【Cell Sub-Journal】New clinical decision?

This article is original from Translational Medicine Network, please indicate the source for reprinting 

Author: TMZHI

Introduction: The emergence of immunotherapy in recent years has greatly changed the pattern of tumor treatment, and recent studies have shown that dietary factors have a significant impact on the effect of immunotherapy

Recently, researchers from the FIRC Institute of Molecular Oncology in Milan, Italy, published a study in "Cell Reports" "Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects", which shows that fasting can make immunogenic Low-risk breast cancer is more effective for immunotherapy, and at the same time reduces drug toxicity

Doi: 10.

Research Background

 01 

Immunotherapy has achieved high success in the treatment of melanoma, lung cancer and colorectal cancer, but most patients do not respond well to immunotherapy due to, among other reasons, tumor immunogenic expression, and its effectiveness is limited to specific cancer types , while no breakthrough results have been achieved in patients with low immunogenicity

In recent years, studies have found that under fasting simulated (FMD) conditions, the immune system can be rapidly rejuvenated, and it can have a strong sensitization effect on radiotherapy, chemotherapy, endocrine therapy and even targeted therapy

research process

 02 

To clarify the effect of fasting on immunotherapy, the researchers constructed a mouse model of breast cancer with low immunogenicity and treated the mice with OX40 and PD-1 inhibitors with or without fasting intervention

Figure 1.

To clarify the mechanism by which fasting sensitizes breast cancer mice to immunotherapy, the researchers examined the effect of fasting on immune cells by single-cell sequencing

Figure 2.

Because immunotherapy induces more frequent toxic side effects, its application is limited

Figure 3.

Significance

 03 

Fasting therapy has been shown to improve the sensitivity of cancer patients to chemoradiotherapy, endocrine therapy, and targeted therapy, but the effect on immunotherapy is unknown

References:

Cortellino S, Raveane A, Chiodoni C, et al.

Note: This article is intended to introduce the progress of medical research and cannot be used as a reference for treatment plans
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