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This article is the original of translational medicine network, please indicate the source when reprinting
Author: Jevin
Type II diabetes is characterized by obesity-associated insulin resistance, which is associated
The team of Professor Bi Yan of the Department of Endocrinology of Gulou Hospital Affiliated to Nanjing University School of Medicine, and The team of Professor Zhang Chenyu and Associate Professor Li Liang of the School of Life Sciences of Nanjing University published a research paper in Cell Metabolism, which for the first time found that exosomes mediate fat-brain communication and promote the occurrence
tissue-brain communication
01
Diabetes significantly increases the risk of cognitive impairment and dementia, posing a great threat
Abnormal adipose tissue function plays an important role
Exosomes are directly involved in the development of diabetic cognitive dysfunction
02
Bi Yan's research group at Gulou Hospital, Nanjing University School of Medicine used fat grafting to study the role of
In order to further investigate whether exosomes derived from adipose tissue are directly involved in the occurrence of diabetic cognitive dysfunction, the researchers treated normal mice with exosomes derived from fatty tissue in high-fat mice and diabetic patients by tail vein injection and hippocampal stereotactic injection, respectively, and the results showed significant synaptic loss and cognitive function impairment
Prevention of cognitive impairment in diabetes
03
Previous research has shown that miRNAs are key molecules that function biologically in adipose tissue exosomes
Finally, the team studied the relationship
Resources:
This article is intended to introduce the progress of medical research and cannot be used as a reference for
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