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This finding may provide new strategies
"Cryptococcal cells in the lungs are very diverse, with different sizes and different appearances
This fungus can quickly adapt to the microenvironment in the body
Brown's fascination with the fungus came from observing it thrive in many different habitats
Previously, other scientists have found that the fungus copes with life in the lungs by growing to 10 times its normal size, possibly because the host's immune system cannot be destroyed
To find out, her team contracted Clostridium neoplasmosis of different sizes
The evidence suggests that the small fungal cells that Brown calls "seed" cells aren't just miniature versions
After searching for triggers, Brown's team discovered a special chemical — phosphate — that can induce this shift
From guano to the brain
Curiously, the fungus's ability to effectively target the brain may stem from a unique source: bird droppings
Brown thinks this could prove how the pathogenicity of the fungus was initially produced
Regardless of how the fungus is contagious, Brown's team is now trying to stop that ability
In addition to Brown, co-authors include Steven T.
The study, published as "A Transmissible Morphological Type Enhances the Ability of the Fungus Cryptococcus Neococcus to Enter Extrapulmonary Organs," was supported
Journal Reference:
Steven T.
