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On November 3, 2022, the team of Professor Guoli Ming and Professor Hongjun Song of the University of Pennsylvania published a publication in the journal Cell Stem Cell: A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan research paper
.
This study established a molecular map of a variety of human glial cells and their subpopulations, including astrocytes, oligodendrocytes and their precursor cells and microglia, at all ages after human birth, and further clarified the application value of the reference map to the analysis of multiple types of single-cell, including the evaluation of in vitro differentiation models based on human stem cells, and the exploration of molecular pathology of brain diseases such as Alzheimer's disease
。
Glial cells have a significant impact on brain development and disease and also change dynamically with age, however the molecular diversity of human glial cells and their subpopulations at all ages remains unknown
。 In this study, human hippocampal samples of five age groups were collected from infants, young children, adolescents, adults and the elderly, and single-cell transcriptome sequencing analysis was used to establish a transcriptome-level reference map
.
The study analyzed in detail the molecular characteristics of different subpopulations of astrocytes, oligodendrocytes and their precursor cells and microglia, and revealed their association
with specific physiological functions, changes in abundance with age, and disease correlation.
Importantly, the study illustrates two applications
of this reference map.
First, the research team compared the reference map with multiple existing stem cell-based in vitro differentiation models to evaluate
the glial cell subtypes.
Secondly, the authors used reference maps to investigate
the molecular pathology of glial cell subsets in Alzheimer's disease.
The publication of this study has greatly expanded the understanding of glial cell diversity, molecular changes in subpopulations of various ages, and dysregulation in neurological diseases, and provided an important reference map
for in vitro differentiation of stem cell-based glial cells.
Links to papers: https://doi.
org/10.
1016/j.
stem.
2022.
09.
010
open for reprinting Welcome to forward to Moments and WeChat groups
.
This study established a molecular map of a variety of human glial cells and their subpopulations, including astrocytes, oligodendrocytes and their precursor cells and microglia, at all ages after human birth, and further clarified the application value of the reference map to the analysis of multiple types of single-cell, including the evaluation of in vitro differentiation models based on human stem cells, and the exploration of molecular pathology of brain diseases such as Alzheimer's disease
。
Glial cells have a significant impact on brain development and disease and also change dynamically with age, however the molecular diversity of human glial cells and their subpopulations at all ages remains unknown
。 In this study, human hippocampal samples of five age groups were collected from infants, young children, adolescents, adults and the elderly, and single-cell transcriptome sequencing analysis was used to establish a transcriptome-level reference map
.
The study analyzed in detail the molecular characteristics of different subpopulations of astrocytes, oligodendrocytes and their precursor cells and microglia, and revealed their association
with specific physiological functions, changes in abundance with age, and disease correlation.
Importantly, the study illustrates two applications
of this reference map.
First, the research team compared the reference map with multiple existing stem cell-based in vitro differentiation models to evaluate
the glial cell subtypes.
Secondly, the authors used reference maps to investigate
the molecular pathology of glial cell subsets in Alzheimer's disease.
The publication of this study has greatly expanded the understanding of glial cell diversity, molecular changes in subpopulations of various ages, and dysregulation in neurological diseases, and provided an important reference map
for in vitro differentiation of stem cell-based glial cells.
Links to papers: https://doi.
org/10.
1016/j.
stem.
2022.
09.
010
open for reprinting Welcome to forward to Moments and WeChat groups
