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Researchers at the University of Birmingham have discovered a new way for cancer cells to repair DNA dama.
These new findings shed light on how cancer cells respond to chemotherapy and radiation therapy, as well as reveal new ways in which cancers develop resistance to targeted therapi.
Repairing DNA damage is essential for cells to stay healthy and prevent the development of diseases such as canc.
In the study, published today in the journal Molecular Cell, a team of researchers from the University's Institute for Cancer and Genome Sciences has identified two previously undiscovered proteins involved in DNA repa.
These proteins, called SETD1A and BOD1L, modify DNA-binding histon.
Associate Professor Martin Higgs, lead author of the study, explained: "This is the first time that these genes have been found to be directly involved in DNA repair in canc.
The team hopes that this work will eventually lead to the development of new inhibitors that could allow clinicians to resensitize cancers that are resistant to certain therapi.
