-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
CAR-T cell therapy harnesses the immune response to cancer by introducing tumor-detecting molecules into T cells .
CAR-T CAR-T cell therapy exploits the immune response to cancer by introducing tumor-detecting molecules into T cells .
On March 10 , 2022 , the team of Associate Professor of Genetics at Yale University, Sidi Chen , published a paper entitled: A genome-scale gain-of-functionCRISPRscreen in CD8 Tcellsidentifies proline metabolism as a means to enhance Research paper on CAR-T therapy.
Using CRSIPR screening technology, the study discovered a way to boost tumor-attacking T cells, a discovery that promises not only to improve the effectiveness of a promising cell-based cancer immunotherapy, but also to expand the cancers it can treat quantity
The Sidi Chen lab devised an ingenious method to efficiently scan the genome of CD8 T cells and unbiasedly identify (look for) genes that might enhance their function .
The Sidi Chen lab devised an ingenious method to efficiently scan the genome of CD8 T cells and unbiasedly identify (look for) genes that might enhance their function .
" We developed a new genome-wide gain-of-function screen to discover molecular enzymes that act like stepping on the gas pedal to increase the metabolic activity of screening T cells, " said Professor Chen
They found that high activity of several genes, including PRODH2 , stimulated increased CAR-T cell activity in mouse models of three different types of cancer , including solid tumor breast cancer .
They found that high activity of several genes, including PRODH2 , stimulated increased CAR-T cell activity in mouse models of three different types of cancer , including solid tumor breast cancer .
Using these systems and findings, future studies can test novel metabolically enhanced CAR-Ts in clinical settings , identify other T - cell superchargers, and expand to different cancer types, especially solid tumors
Ye Lupeng, Jonathan Park , Peng Lei and Yang Quanjun from Yale University are the co-first authors of the paper, and Chen Sidi is the corresponding author
Paper link:
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy.
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy.
Cell Metabolism.
https://doi.
org/10.
1016/j.
cmet.
2022.
02.
009
here message