Cell: Study reveals immunological characteristics of brain tumors

June 1, 2020 /PRNewswire/--- Recently, a comparative analysis from Ludwig Cancer Research outlines the unique immunological characteristics of brain or gliomas and tumors that are transferred from the lungs, breast and skin to the organsThe study was led by Johanna Joyce and published in the journal CellThe study detailed the function, location, and characteristics of various immune cells that shape tumor microenvironments (TME) to prevent immune attacks, support cancer cell survival and drive tumor progressioncancer selectively utilizes various immune cells and even manipulates their gene expression procedures, allowing them to suppress anti-tumor immune responses, help metastasis, build blood supply and provide other critical supportNow, targeting such immune cells, or "re-educating" them to attack host tumors, has become the focus of cancer immunology"Our findings underscore that we cannot take a one-size-fits-all approach to brain cancer," Joyce said(photo source:In their study, Joyce and colleagues looked at the number and priority of 14 subtype immune cells in 100 brain tumor samples taken from patientsThey also analyzed the expression spectrum of proteins in the samples and the overall gene expression patterns of individual immune cellsThey then combined these detailed large-scale analyses to fully map the immunological characteristics of each tumor type and capture differences in the functional state of their resident immune cellsthis comparative analysis shows that five types of immune cells are associated with brain TMEThese include monocytose-derived macrophages, small glial cells, neutrophils; CD4-T cells, CD8-(killer) T-cellsThe specific composition of immune function and the functional state of the cells that make up it are formed by the brain's unique biological interactions and the innate characteristics of each tumorJoyce said: "In the course of studying TME, we have to look at different types of brain malignanciesWe can't just combine them all together and hope that a treatment will work for all of these diseases"
researchers show that small glial cells dominate early gliomas, characterized by a mutation in an enzyme called IDH Advanced gliomas or glioblastomas (GBM) associated with normal IDH genes have a large number of macrophages that migrate from blood circulation to the brain "Therapy that prevents macrophages from getting into the brain may be more beneficial to the treatment of advanced gliomas than eliminating small glial cells," Joyce said (Bio Valley Bioon.com) Source: Ludwig Cancer Research Research Profiles profiles of the mummy s iamin of brain origin: Klemm F, Maas RR, Bowman RL, Kornete M, Soukup K, Nassiri S, Brouland JP, Iacobuzio-Donahue CA, Brennan, Ta bar Of the micro-environmental landscape in brain tumors reveals disease-specifics of immune cells.
Cell (May 28, 2020) DOI: https://doi.org/10.1016/j.cell.2020.05.007.