Cell: Solved nearly a hundred years of problems! The study found the underlying pathways of "swinging through" memory.

From reading newspapers to crossing busy intersections, working memory is widely used.
working memory disorders are particularly prominent in learning disabilities, aging, attention deficit ADHD, Alzheimer's disease and schizophrenia.
working memory is a form of short-term memory, involving the maintenance and updating of task-related information in order to achieve the goal-oriented pursuit.
classical models position sustained activity in the pre-cortical cortical layer (PFC) as the main neuro-related factor, but emerging views suggest that other mechanisms may exist.
September 29, 2020, Kuangfu Hsiao of Rockefeller University and others published a research paper on Cell Online entitled "A Thalamic Orphan Receptor Drives Variability in Short-Term Memory", which screened about 200 mice with genetic diversity in working memory tasks and identified genetic site on chromosome 5, which accounts for a large portion of the phosphase variation (17%).
in the gene base, the study identified a gene that encodes Gpr12, an orphan G protein concoged, that drives substantial and bidirectional changes in working memory.
molecular, cellular, and imaging studies have shown that Gpr12 enables a high degree of synchronation of the pasalpycleus-PFC, thus supporting memory maintenance and selection accuracy.
these findings confirm that orphaned subjects are effective modifiers for short-term memory, and complement the classical PFC-based model with a framework centered on the emerging pasalpyric brain, thus providing a mechanism understanding of working memory.
from reading newspapers to crossing busy intersections, working memory is widely used.
working memory is a memory system with limited capacity for temporary processing and storage of information, which plays an important role in many complex cognitive activities.
More precisely, working memory is (1) the ability to temporarily store task-related information from a few seconds to a few minutes without sensory input, while (2) using that information for purposeful pursuits, maintenance (for example, remembering the first sentence in a newspaper) and manipulation (anticipating what happens next).
this dual process requires a high degree of attention and cognitive needs and is associated with intellectual and senior management functions.
working memory disorders are particularly prominent in learning disabilities, aging, attention deficit ADHD, Alzheimer's disease and schizophrenia.
early lesions (1936) determined the basic role of the pre-pre-cortical cortical layer (PFC) in working memory.
followed neurophysiological studies in primates and rodents.
study identified a neural association with working memory: the continuous discharge of cortological neurons.
this continuous discharge lasts from a few seconds to a few minutes, it's incredible because it far exceeds the millisecond constant of a single neuron.
the pattern map (pictured from Cell) Despite decades of research, there is a lack of consensus on the brain mechanisms that produce this sustained activity.
some models suggest cell autonomy processes, while others propose local feed-forward or recurrence activity or long-distance loops.
increasing attention has been paid to mechanisms other than ongoing activities, particularly in view of multi-item storage and high anti-jamming.
, a more complete model is needed.
past, unbiased genetic graphing methods reveal the basis of basic molecular mechanisms that can link neurophysiology and behavior.
Despite their powerful capabilities, these pioneering gene matographing methods in invertebrates are limited by (1) graph resolution and (2) inability to assess higher-order cognitive processes such as selective attention and working memory.
to draw inspiration from these methods and address the obvious limitations, the researchers used diversity in recent (DO) resources to quantify the genotyptic genotypor base (QTL) in genetically diverse mice.
DO mice represents a unique mosaic of the parent and is highly hybrid.
together, they provide an ideal platform for high-resolution gene matographing.
, DO and other genetic diversity queues have been used in a series of studies that associate genetic constellations with multiple veons.
the emergence of this resource, along with advances in gene editing and graphing techniques, provides new opportunities for the unstoeable exploration of the molecular and neural loop mechanisms of working memory.
, the researchers performed esopic analysis on about 200 DO mice during a working memory mission and identified a significant QTL on chromosome 5.
Further examination of the gene base through gene expression, loss of function and behavioral studies revealed a gene that encodes the orphan G protein concoged subject Gpr12, which is necessary for working memory and can functionally promote working memory.
subsequent molecular, cellular, and in vivo imaging studies have shown that GPR12 is located in the synapses of the cerebral cortical neurons, promoting an activity-dependent calcium response and allowing the cerebral cortical synchronously supports behavioral performance.
results highlight the important contribution of the psych brain, which relies on Gpr12, to working memory.
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