Cell: Reveals the antiviral immune response points of targeted tumors in triple-negative breast cancer...

In a recent study published in the international journal Cell, scientists from the Baylor School of Medicine and others in the United States revealed therapeutically targeted RNA shearing or activating antiviral immune pathlines in triple-negative breast cancer, causing tumor cells to die and immunized the body. The response signals; the researchers point out that faulty scissors of RNA in tumors can milynate RNA viruses, allowing tumor cells to self-destruct as if they were fighting infection; a mechanism that could help open up new ways to activate immune system function in malignant cancers such as triple-negative breast cancer.
researcher Trey Westbrook said: 'We all know that treatments that partially interfere with RNA shearing may have a significant impact on tumor growth and progression, but the mechanisms behind the tumor's lethal effects are not yet clear to researchers; Inclusions, which usually lose regulation in tumors, cause tumors to grow and promote tumors to become highly sensitive to sputum targeted therapy (STTs, spliceosome-targeted therapies), one of the malignant cancers that is very sensitive to STTs.
the study, researchers wanted to understand the molecular mechanisms by which these drugs interfere with tumor progression, and they found in triple-negative breast cancer cells that STTs can interfere with RNA shearing and promote endogenetic mis stitching of endogenetic RNA in tumor cell cytestyles. As they accumulate, many of these abnormal RNAs form double-stranded structures, as if they were RNA viruses; antiviral immune path pathps recognize double-stranded RNA, which then induces apoptosis and sends signals to the body's immune system to induce inflammatory reactions. 'Our study reveals a new way to activate the body's inflammatory response by specifically targeting cancer cells,' said Dr. Elizabeth Bowling,
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Now researchers have a clear understanding of how high levels of false shearing can cause cellular stress in breast cancer cells, and they speculate that RNA shear stress may be present in many cancer types and disease states. the
study, which is expected to help researchers find new biomarkers to screen patients who can respond to current immunomodulation therapies, in particular, suggests that endogenetic missharding of RNA in tumor cells may stimulate the body's immune system, even in the absence of STT therapy, and that the data reveal a link between mis stitched RNA and immune characteristics, even in immune "cold tumors."
the researchers speculate that this endologically misshared RNA may be used as a clinical biomarker to find out which cancer becomes sensitive to immunotherapy, and later they need to do more in-depth research to determine whether the activation of the anti-tumor immune path line STTs will make more cancer patients suitable for immunotherapy.
Finally, researchers say that because immunotherapy still works in a small percentage of cancer patients because of its far-reaching therapeutic effects, researchers must learn how to expand the range of patients who can benefit from immunotherapy, and the findings reveal new mechanisms of dialogue between cancer and the immune system that could help develop new strategies to benefit more cancer patients.
original source: Elizabeth A. Bowling, Jarey H. Wang, Fade Gong, et al. Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer, Cell (2021). DOI:10.1016/j.cell.2020.12.031 This article was originally sourced from Bio Valley, please download Bio Valley APP for more information (