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In summary, the authors found two groups of specific neurons in the solitary beam nuclei that conduct sweetness and bitter taste, on the basis of which the neuromodulation mechanism behind the phenomenon of bitter taste suppressing sweetness is expounded.
this mechanism relies on two positive and negative feedback paths from the bitter cortical layer and the amygdala.
These two feedback paths act as the only portal for the outer taste information of the lone beam nucleus to enter the brain, ensuring that the bitter taste is 'better than' sweet by amplifying the bitter signals that enter the brain and weakening the sweet signals that enter.
study is important for understanding how the "Hardwired circuit" of taste regulates adaptive behavior.
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