Cell: Reveals immune pathology characteristics of PATIENTS WITH COVID-19 CRITICAL ILLNESS WITH HOST-VIRAL VIRUS SPECTRUM

2020 May 14 News /BioValleyBIOON / - Currently, COVID-19 continues the pandemic, the virus constitutes a continuing threat to global healthCurrently, however, the lack of human host data how it interacts with the virus, including SARS-CoV-2 virus, including, limiting researchers and physicians to develop and use effective therapeutic intervention strategiesRecently, Professor IdoAmitDepartment of Weizmann Institute of Science in IsraelImmunology, National Institute of Infectious Diseases and Clinical Research Center for Liver Diseases Third People's Hospital of Shenzhen ZhengZhang cooperation Professor Professor ShuyeZhang, BennoSchwikowsk professor at Institut Pasteur and CNRS Institute of Fudan University and the Shanghai public health clinical Center of Biomedical published an article in the journal Cell, by drawing the host - viral infection spectrum reveals 19 COVID-severe patients the feature article titled "Host-viralinfectionmapsrevealsignaturesofsevereCOVID-19patients"a Source: Cellhighlights of the study include:Virus Tracking: researchers developed a host analysis - computational framework infection spectrum;infected cell infection virus tracking sorting revealed a virus-induced gene expression;found SARS-CoV-2 infected epithelial cells and immune function in patients with severe changes;found simultaneously infected SARS-Cov-2 and will hMPV monocyte and inhibition of interferon responsestudy personnel tracking virus (Viral-Track), which is a calculation method, it can be the global scan of the scRNA-seq unmapped data to find the presence of viral RNA in the infected cells in order to achieve and bystander cells of transcription of the sortresearchers demonstrated the virus tracking system to detect the sensitivity and specificity from a variety of viral infection models, including an unsupervised way to detect hepatitis B virustrack of the virus by bronchial lavage samples COVID-19 patients with mild and severe, the researchers found to affect the immune system in patients with severe viral significantly greater than in patients with mildaddition, researchers are tracked using a virus is detected accidentally during joint infected with human metapneumovirus, mainly in the type I interferon signaling pathway in monocytes impairedgeneral, researchers developed a virus tracking technology provides anatomical and pathological mechanisms of viral infection a strong technical support, disclosesimmunologically different symptoms among patients
feature, is expected to provide personalized recommendations reference therapeutic administration of different patient's symptomsa (Biovalley Bioon.com) References:.PierreBostetalHost-viralinfectionmapsrevealsignaturesofsevereCOVID-19patientsCell.2020.DOI: https: //doi.org/10.1016/ j.cell.2020.05.006