Cell Research: The latest research advances in SARS-CoV-2 serology between Zhong Nanshan and other teams and hospital patients in China.

As of July 22, 2020, there are more than 14.89 million confirmed cases and 610,000 deaths worldwide, according to real-time statistics released by Johns Hopkins University.
the popularity of COVID-19 in China is now under control, thanks to China's swift and strong measures.
addition to some imported cases from abroad, there are very few new cases in China.
SARS-CoV-2 asymptomatic infection means that the patient does not have relevant clinical symptoms (e.g. fever, cough, sore throat and other self-aware or clinically recognizable symptoms and signs), but respiratory and other specimens of neo-coronaviral pathogens (usually refers to nucleic acid testing) or serum-specific immunoglobulin M (IgM) antibodies tested positive.
risk of transmission for asymptomatic infections.
, the prevalence of asymptomatic infections in China and around the world is unclear.
July 20, 2020, a research paper entitled "Serosurvey of SARS-CoV-2 hospital visitors in China", led by Zhong Nanshan, a member of the Chinese Academy of Engineering, investigated the positive rate of SARS-CoV-2 IgM/IgG antibody in the serum of 17,054 hospital patients.
, COVID-19 diagnosis is mainly based on PCR test results, combined with clinical symptoms.
serological survey can fully identify people infected in the community, especially asymptomatic infections.
IgM antibody-positive indication in the serum is in the early stages of infection, while the IgG antibody-positive and lasts longer after onset, suggesting a previous infection.
latest study from the United States showed a 100% positive rate for antiviral immunoglobulin in patients with neo-corona pneumonia.
antibody detection false negative rate of 10%-15%, but can detect asymptomatic infection, can more accurately estimate the true infection rate of the population.
serum survey in Santa Clara County, California, found that SARS-CoV-2 infection rates may be 30-50 times higher than official reports based on nucleic acid diagnosis.
researchers analyzed the SARS-CoV-2 IgM/IgG antibody sero-positive rate of patients at Guangzhou Medical University First Affiliated Hospital in Guangzhou, the largest city in southern China, and Hubei Cancer Hospital in Wuhan, the center of the outbreak.
As of April 30, the Wuhan queue (center) included 8,272 people, and the Guangzhou queue (non-center) included 8,782 people, with the median age being 54 years (44-62 years) and 55 years old (38-67 years old).
all subjects tested negative for SARS-CoV-2 RNA, and most did not show symptoms associated with neo-coronary pneumonia in the past three months.
IgM/IgG positive rates in Wuhan and Guangzhou queues were 2.1% and 0.6%, respectively.
in Wuhan, the IgG-positive rate of SARS-CoV-2 in the serum was higher than that of IgM.
sero-positive rates in the gender and age subse groups were not significantly different.
researchers analyzed the trend of IgM and IgG in Guangzhou Queue Hospital over time and found that the trend was consistent with the "Twin Peaks" of the total number of RNA-positive (RNA-plus) cases in Guangzhou, but with a slight delay.
study was conducted on hospital patients who tested negative for SARS-CoV-2 RNA and had no symptoms associated with neo-coronary pneumonia.
but the study found that the population still tested positive for SARS-CoV-2 antibodies.
, there is no consensus on whether asymptomatic infections are contagious.
Zhang Guojun, head of the group of experts on medical treatment of Xinguan pneumonia in Henan Province and director of the Respiratory and Critical Medicine Department of the First Affiliated Hospital of Zhengzhou University, said that "asymptomatic people can also become a source of infection, with a certain risk of transmission."
as a result, asymptomatic infected persons are still under quarantine observation to avoid a second outbreak.
study, the serum-positive rate in Wuhan was higher than that in Guangzhou, and the trend of RNA-positive cases in Guangzhou was consistent with the antibody-positive rate of the patients.
because of the sensitivity of the test, the actual sero-positive rate may be higher.
, but there is no denying that the relatively low sero-positive rate once again confirms the effectiveness of China's preventive control measures.
, the study found that population immunity remained low, whether or not they were at the center of the outbreak.
, an effective SARS-CoV-2 vaccine is urgently needed.
, before the vaccine came out, we can not have the slightest slack, should continue to take strict isolation and community measures, the national effort, we will certainly win this epidemic resistance war!