Cell: Research reveals the molecular mechanisms of exercise that make people healthy! And the development of new detection methods!

June 2, 2020 /
PRNewswire
2020 -- A simple blood test may determine your condition, according to a new study by scientists at Stanford University School of Medicinethis test can be used as a complement to the treadmill test, a more traditional clinical method of health assessment that provides individuals with more nuanced information about their bodies' molecular responses to exerciseblood testing is a branch of a complex study conducted by a team of researchers who measured hundreds of thousands of molecular measurements from a group of individuals before and after exercise"Everyone knows exercise is good for you, but we really don't know what drives it at the molecular level," says DrMichael Snyder, professor and chair woman atGenetic s
"Our initial goal was to conduct a highly comprehensive analysis of the physical condition after exercise"
picture source; Cellteam tracked molecular markers of a range of biological processes, such as metabolism, immunity, oxidative stress and cardiovascular functionHundreds of thousands of measurements from 36 study participants provided a window into the chemical fluctuations the body experienced during intense exerciseAs far as scientists know, a comprehensive measurement of molecular fluctuations after this movement has never been doneIn addition, the team found that the healthiest participants had similar molecular characteristics in resting blood samples taken before exercise"It gives us the idea that we can develop a test to predict a person's health," said Dr Kevin Contrepois, director of metabolic and lipid groupings at the department of genetic "Aerobic fitness is one of the best ways to measure life expectancy, so a simple blood test can provide this information, which is very valuable for personal health monitoring "
have these preliminary data, the team created a principle validation test and filed a patent application for it The test is not currently open to the public A paper describing the study was published May 28 in the journal Cell a series of changes
Snyder's team set out to better understand the molecular changes behind physical changes The gold standard for medical health assessment is a peak VO2 test that measures a person's peak oxygen consumption during high-intensity exercise and uses this score as an indicator of aerobic fitness But Snyder and his team want more details, especially about how motion triggers change at the molecular level they tested VO2 on a treadmill for 36 people, including Snyder Participants, male and female, had an average BMI of 29 kg/m2 and an age range of 40 to 75 years Before the treadmill test, the researchers drew a baseline blood sample The participants then put on an oxygen measurement mask and ran at a slightly tilted angle until the oxygen consumption peaked, then stopped running and left the treadmill The researchers took blood samples two, 15, 30 and 60 minutes after the participants reached their peak "All of these measurements allow us to describe changes in molecular events that occur after motion," Snyder said "We know that exercise leads to a range of physiological reactions, such as inflammation, metabolism, and hormonal fluctuations, but these measurements allow us to describe these changes in unprecedented detail "
results show that in the first two minutes after exercise, the body experiences a series of intense molecular activity In most of the participants, molecular markers of inflammation, tissue healing, and oxidative stress, a natural by-product of metabolism, rose sharply shortly after they jumped off the treadmill, and then the body began to recover Metabolic molecular markers vary, Snyder said After 2 minutes, blood samples showed that the body was metabolizing certain amino acids for energy, but after about 15 minutes, it metabolized glucose-- a sugar "The body breaks down glycogen as part of its exercise recovery response, so that's why we see that peak a little later," Snyder said Glycogen is a form of glucose storage As part of the study, Snyder also compared insulin resistance to individual synors' molecular responses, which meant they could not process glucose properly "The main difference we see is that insulin-resistant individuals have a weak immune response after exercise, " he said image source: https://cn.bing.com
blood health tests
although this was not the team's intention, they noted some consistency in baseline measurements of participants who performed better in the peak VO2 test In these individuals, the researchers found a strong correlation between a group of molecules and anaerobic energy levels in individuals They found a collection of thousands of molecules, including markers of immunity, metabolism, and muscle activity, which are associated with a person's aerobic fitness "At this point, we don't fully understand the connection between these markers and how they relate to better health," Snyder said The researchers hope to unravel these links in future investigations Snyder says that because the molecular mapping analysis done in this study is so thorough, it is unrealistic for doctors to use it in clinics; it would be expensive and provide more unnecessary information But his team is working to reduce the of biomarkers to the level that best represents a person's health level, making the test useful in a wider range of applications Contrepois said the team is already developing an algorithm to select a subset of these molecules that are highly relevant to the VO2 peak results As researchers continue to optimize their health tests, they hope that one day it will become a faster, cheaper and more convenient way for people to measure aerobic fitness objectively (biovalleybioon.com) Reference: Study details molecular effects of exercise
K?vin Contrepois et al.
Molecular At Acute Exercise Cell 2020 DOI: https://doi.org/10.1016/j.cell.2020.04.043