Figure 2 Light reactions and morphology of Patch-seq RGCs belonging to the transcriptome C16_ooDS_DV

(Source: Huang W.

This study provides morphological and functional annotations
for 19 Novel transcriptome types.

For example, for a cell whose transcriptome belongs to a cell named C10_Novel (Figure 3A), the findings are all present with ON responses and morphologies that all belong to the 7i/7o type
.

These cells are characterized by
a large dendritic area, a single layering of dendrites in the inner plexus layer, and coincidence with the branches of starburst-free long-process cells located in the GCL layer.

For example, the transcriptome belongs to a cell named C39_Novel (Figure 3B), which belongs morphologically to type 5si, has the characteristics of small dendritic area but high complexity and more branching points, and its dendrites are widely distributed in the middle of the inner plexus layer, suggesting that such cells may be involved in the processing of high-resolution images; In terms of function, this part of the cells exhibits the color selectivity characteristics
of ON-OFF under blue light and ON under green light.

These characteristics of C39_Novel suggest that they may be involved in high-resolution visual formation
.

In the case of cells whose transcriptome belongs to C34_Novel (Figure 3C), although morphologically dendrites are also distributed near the middle layer of the inner plexus, they are functionally present as an ON response
.

Figure 3 The transcriptome belongs to the light response and morphology of C10_Novel, C39_Novel, and C34_Novel Patch-seq RGCs

(Source: Huang W.

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[2] Transl Psychiatry—Early impairment of cortical circuit plasticity and connectivity in mouse models of Alzheimer's disease

[2] J Neurosci-Li Shao/Ma Tonghui team revealed the orthogonal array structure of AQP4 in aquaporin point mutation depolymerization mice and reduced its polar distribution at astrocyte ends

[4] Cereb Cortex—Yu Yuguo team-built a human brain energy and activity map to reveal the law of energy distribution

[5] J Neurosci—Li Shao/Ma Tonghui team revealed the orthogonal array structure of AQP4 in aquaporin point mutation depolymerization mice and reduced its polar distribution at astrocyte endpoda

[6] Cereb Cortex—Yu Yuguo team-built a human brain energy and activity map to reveal the law of energy distribution

[7] Inflamm Regen—Wu Anguo/Qin Dalian/Wu Jianming's team revealed that the seedling medicine to catch the yellow herb active monomer improves the pathology of Alzheimer's disease

[8] Transl Psychiatry—Reticular meta-analysis: Drug treatment strategies for hyperprolactinemia caused by antipsychotics

[9] Nat Metab-Xiong Wei's research group elucidated a new target for alcohol and cannabis to synergistically lead to sports toxicity

[10] PloS Genet—Lingyan Xing/Liucheng Wu/Junjie Sun collaborated to reveal a new mechanism of non-cellularized degeneration of motor neurons in spinal muscular atrophy

Recommended for high-quality scientific research training courses

[1] R Language Clinical Prediction Biomedical Statistics Training (October 15-16, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing)

Conference/Forum Preview & Review

[1] Trailer | Conference on Neuromodulation and Brain-Computer Interface (U.

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References (swipe up and down to read)

[1] Tran NM, Shekhar K, Whitney IE, Jacobi A, Benhar I, Hong G, Yan W, Adiconis X, Arnold ME, Lee JM, Levin JZ, Lin D, Wang C, Lieber CM, Regev A, He Z, Sanes JR.

[2] Bae JA, Mu S, Kim JS, Turner NL, Tartavull I, Kemnitz N, Jordan CS, Norton AD, Silversmith WM, Prentki R, Sorek M, David C, Jones DL, Bland D, Sterling ALR, Park J, Briggman KL, Seung HS; Eyewirers.