Cell Reports: Pointing out a new direction for the development of a durable new crown vaccine!

Research results indicate that a component of this protein, the viral polymerase, may be added to the COVID-19 vaccine to generate a longer-lasting immune response and increase protection against new variant viruses

Most COVID-19 vaccines use part of the spike protein found on the surface of the virus to promote the immune system to produce antibodies

One way to achieve this goal is to add a different viral protein fragment to the vaccine-this viral protein is less susceptible to mutation than the spike protein and activates the T cells of the immune system

The researchers focused on the viral polymerase protein, which is not only found in SARS-cov -2, but also in other coronaviruses, including those that cause SARS, Middle East respiratory syndrome, and the common cold

To determine whether the human immune system has T cell receptors that can recognize viral polymerases, the researchers exposed blood samples from healthy human blood donors (collected before the COVID-19 pandemic) to viral polymerase antigens

More than 5 million people worldwide have died of COVID-19

UCLA graduate student Pavlo Nesterenko is the first author of the study; the corresponding author is Dr.

The research was published today in the online edition of Cell Reports

This research received the Parker Institute of Cancer Immunotherapy, the National Institutes of Health's Ruth L.

Journal Reference :

1. Pavlo A.

   
   

University of California-Los Angeles Health Sciences.

University of California-Los Angeles Health Sciences.