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Hematopoietic stem/progenitor cells (HSPCs) can differentiate into lymphoid, myeloid, and red blood cells, mainly in the bone marrow microenvironment, are regulated by cells in the microenvironment, and are in a state
of physiological hypoxia.
On September 20, 2022, the Lu Xinjiang Research Group of the School of Basic Medicine of Zhejiang University published a research paper "Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization" online in the journal Cell Reports.
In the study, the researchers first observed high expression of Metron in bone marrow macrophages and proposed a hypothesis for this: Metrn secreted by macrophages may be involved in HSPC homeostasis
.
The researchers conducted an in-depth study through transcriptome sequencing and found that PLC signaling within HSPC cells is activated in macrophage-specific Mestrand knockout mice, and activated PLCs can increase ROS levels by modulating the expression of Nr4a1 and Alox15, thus revealing the intracellular signaling pathway
in which Mestrn regulates HSPC mobilization.
Lu Xinjiang, a researcher at the School of Basic Medicine of Zhejiang University, is the corresponding author of this paper, and Dai Youwu and Ma Junjiao, graduate students of the Lu Xinjiang Group of Zhejiang University, are the co-first authors
.
Original Source:
You-Wu DaiJun-Kai MaRui Jiang, et al.
