Cell Rep: uncovering the molecular mechanism of brain evoking memory

December 9, 2019 / BIOON / -- recently, a report was published in the international journal Cell reports In the previous report, scientists from Florida International University uncovered the mechanism of how the brain recollects memory in the right order through research; the relevant research results are expected to help understand the mechanism of diseases such as Alzheimer's disease affecting brain memory, and help develop new therapies for such diseases Photo source: cc0 public domain when we complete tasks or recall with family members, it is a very important skill to recall the brain in the right order However, it is still one of the mysteries of how the brain works today In this paper, the researchers analyzed the roles of different parts of the brain and how to retrieve and remember them in a certain order The researchers trained rats to remember the order of odors, then scrambled the order of these odors, and ordered the rats to sequence these odors If the order of the rats was correct, they would be rewarded - water Jayachandran, the researcher, said the rats were very good at this task, which can effectively distinguish the order of these odors; in order to simulate the effects of brain disorders, the researchers blocked the ability of different parts of the brain to transmit information between the rats Because of the interference received, the researchers found that the rats could not determine whether their memory lost the order, The researchers then repeated the experiment by interfering with another connection in the rest of the brain, and the results showed that the rats failed again in the task The benefit of doing this task is that researchers can ask animals how they get this information, and it turns out that the animal's pattern of wrong answers is almost the opposite Based on the information the researchers turned off in the rat brain, they found that a particular brain structure was better at remembering the order of events, while the worse the other structure performed in memory, the more disordered the order of smells To clarify the process and mechanism of brain recall memory can help scientists better understand what happens in the brain of patients affected by memory disorders In the future, researchers may be able to improve their ability to recall memory in the right order by manipulating these circuits in the brain of patients Original source: maanasa jayachandran et al Prefrontal pathways provide top down control of memory for sequences of events, cell reports (2019) Doi: 10.1016/j.celrep.2019.06.053