Cell Rep Med: Reveal the key role the immune system plays in the development of severe COVID-19 infections!

13, 2020 // -- In a recent study published in the international journal Cell Reports Medicine, scientists from the Caroline Institute in Sweden and other institutions identified a variety of cell types through in-depth analysis of the immune system activation mechanisms of patients with severe COVID-19, which play a key role in the body's immune response to the new coronavirus and the excessive inflammatory response in severe cases.
photo source: CC0 Public Domain researcher Dr Peter Brodin said the findings were important because they could help improve scientists' clinical assessment of patients and develop new therapies to regulate the body's immune system in patients with severe COVID-19 In the article, the researchers analyzed samples from severe COVID-19 patients treated in Helsinki, Finland, using a combination of advanced technologies to analyze the complete composition and function of the immune system in up to 14 duplicate blood samples per patient.
the study, researchers analyzed in detail the activation of the body's immune system during a severe COVID-19 infection, as well as details of the body's immune system response to viral infections and the high-response characteristics of the body in patients with severe diseases.
researchers found that a type of white blood cell called eosinophils played a key role in a patient's severe COVID-19 infection, after researchers found a clear link between asthma and eosinophils, but they did not know the key role of eosinophils in respiratory infections in the lungs.
researchers say that before patients suffer from excessive inflammation of the lungs, acute respiratory distress syndrome (ARDS) and intensive care, eosinophils expand rapidly in the blood in the short term, and they also found that other white blood cells, such as lye-like granulocytes, Participating in the body's strong antibody response during a patient's infection, the researchers concluded that we also revealed how the body's immune system function recovered in patients with severe COVID-19, and the results provide new clues and ideas for clarifying the key role of the immune system in the process of severe COVID-19 infection.
original source: Lucie Rodriguez, Pirkka T. Pekkarinen, Tadepally Lakshmikanth, et al. Systems-level immunomonitoring from acute to recovery phase of severe COVID-19, Cell Reports Medicine (2020). DOI: 10.1016/j.xcrm.2020.100078.