Cell Rep: Glucotoxin promotes tissue regeneration.

March 20, 2020 /--- millions of Staphylococcus auspicillus bacteria appear on the skin and mucous membranes of the upper respiratory tract.
, in some cases harmless bacteria can become pathogens, leading to skin inflammation and lung infections and, in the worst case, sepsis.
Especially when bacteria multiply too fast, especially when a person's immune system is weakened by infection or injury," said Professor Oleva Werz of Jena Friedrich Schiller University in Germany.
(Photo source: www.pixabay.com) and others have made surprising discoveries by studying the molecular defense mechanisms of the human immune system against Staphylococcus acolytic infection.
results were published recently in the journal Cell Reports.
study found that a toxic mixture of Staphylococcus acobacteria that destroys cells and tissues also has a positive effect: bacterial toxins stimulate specific immune cells to produce specialized messengers that help reduce inflammation and promote tissue healing.
Werz hopes this so far-unknown mechanism will be important for future treatment of skin inflammation and chronic wounds.
their latest study, researchers at the Fritz Lipman Institute (FLI), together with colleagues at Harvard Medical School and the University of Naples, specifically studied the effects of α bacterial toxins on M2 macrophages.
M2 macrophages are immune cells that, later in the inflammatory response, ensure that the killed bacteria and damaged cell components are killed and that tissue regenerates.
researchers have shown that α-hemolyticin binds to specific subject proteins on the surface of M2 macrophages, triggering the production of anti-inflammatory messengers in cells and then causing inflammation to subside.
study, scientists were able to demonstrate that these transmitters promote tissue regeneration in animal models.
(bioon.com) Source: Toxic substance found in Staphylococcus aureus finds tissue regeneration, researchers find Original source: Paul M. Jordan et al, Staphylococcus aureus-derived α-Hemolysin Evokes Generations of Speciality-Solutions Mediators, Reports DOI: 10.1016/j.celrep.2020.108247.