Cell Rep: a new drug or can effectively inhibit the spread of cancer

February 4, 2020 / biool / - recently, in a research report published in the international journal Cell reports, scientists from the Harry Perkins Institute of medicine and other institutions have developed a drug to block the formation of blood vessels around some cancers and the barrier of drug resistance to therapy At the same time, they have also found that these drugs can effectively inhibit the spread of cancer Photo source: Ruth, researcher of Harry Perkins Institute of medical research Ganss said that the drug initially developed by us can overcome some problems in some cancers It can create a disordered blood vessel barrier in tumors, so as to inhibit the body's immune cells and chemotherapy and other therapies to attack the tumors At the same time, the drug can also act on the lymphoid structure in cancer, so as to attract the immune system of patients and greatly enhance the immune system The ability of the patient to shrink the tumor By normalizing blood vessels, these drugs can effectively block the spread of cancer, because they can neutralize the influence of cancer on blood vessels in other parts of the body; when cancer cells start to wander in blood vessels and grow in other organs such as the lung or brain, cancer starts to spread; cancer spread is usually established in remote organs, because the main tumor tissue will release special Special substances make blood vessels in other organs easy to be infiltrated by tumor cells When cancer cells start to wander in the blood vessels, they are usually easy to grow under the best conditions, and eventually form diffuse cancer cells, primary / major tumors The tissue "talks" to the metastasis site to ensure that the cancer cells floating in the blood can reach the metastasis site smoothly; now researchers are very clear about the behavior of these cancer cells, and they can also intervene in the process, because the new drug can effectively affect the function of cancer blood vessels The researchers pointed out that the drug can restore the leaking blood vessels so that the cancer cells can pass through without establishing the focus at the leakage point For a patient, this means that the researchers can effectively remove the primary tumor, and then use the new drug to inhibit the cancer cells in the blood system to successfully establish the metastasis focus But if cancer cells start to settle and grow, the drug can increase the number of immune cells entering new tumors and help them shrink The new drug can help increase the efficiency of immunotherapy for primary tumors, but also inhibit the metastatic spread of cancer If cancer cells have spread, the drug can also enhance the immune response of patients to new cancer; researcher Bo He said that in this study, we focused on the study of metastatic cancer patients, because many patients will have secondary tumors; now researchers have successfully tested the drug in melanoma and lung cancer tumor models, and later they will continue to further study whether the drug can effectively treat other types of cancer Original source: Bo he, Anna Johansson perfect, Joseph Backhouse, et al Removing of metastatic vacuum reductions lung colony and senses over metaspaces to immunology, cell reports (2020) Doi: 10.1016/j.celrep.2019.12.013