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Cell publication reveals the secret behind the threat of non-alcoholic liver disease

 Last Update: 2021-07-31
 Source: Internet
 Author: User

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Figure: Liver fibrosis section showing red collagen fibers

Source: Helmholtz Zentrum München / Anne Loft

Non-alcoholic fatty liver is the most common liver disease in the world, accounting for about 25% of the world's population

Liver fibrosis is a strong predictor of long-term mortality in patients with non-alcoholic fatty liver

Loss of identity can lead to dysfunction

Researchers use comparative genomics to analyze the mechanisms that control the development and special functions of the most abundant cell types in the liver.

The reprogramming of liver cells is a molecular switch tightly controlled by a protein network, the so-called "transcription factor"

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Based on these findings, it is now possible to develop new methods to effectively target certain nodes in the protein network to prevent the progression of the disease and even reverse the existing fibrosis, which is currently impossible

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