Cell: Piezo1 molecule regulates intestinal and bone steady state

, July 8, 2020 /PRNewswire/ --- Previous studies have shown that intestinal chromium-like cells regulate the steady state of the intestines and bones by secreting serotonin (serotonin 5-serotonin)Intestinal microbes can regulate serotonin levels, but their potential molecular mechanisms have not yet been revealedAccording to a recent study, Piezo1 is essential for the intestinal production of serotoninThe researchers have found that rna sources of bacteria can activate Piezo1, causing intestinal chromium-clicocells to produce serotonin, and that the mutual signaling of RNA-Piezo1 may be an important target for the treatment of bone and intestinal diseasesa new study published in the journal Cell by researchers at the National Institute of Physiological Sciences (NIPS), led by DrKenta Maruyama, reveals that intestinal Piezo1 regulates systemic serotonin synthesis through RNAIt has been found that bacterial RNA-stimulated intestinal Piezo1 is critical to the production of serotonin(photo source:serotonin is essential for the normal functioning of the central and peripheral nervous system serotonin to control mood, peristaltic and blood pressureTwo sources of serotonin production include brain neurons and intestinal chromium-ophilisIt is worth noting that serotonin does not cross the blood-brain barrier, and most of the body's serotonin is secreted by intestinal chromium-obsessed cells, making the intestine the main source of local tissue serotoninMost of the intestinal-derived 5-serotonin is absorbed by platelets, which are released under various irritationsThis then leads to the activation of several biological phenomena, such as intestinal peristalsis and enteritisinteresting, a small fraction of the intestinal-derived serotonin is reported to act as a hormoneFor example, serotonin inhibits the formation of bone cellsIt is worth noting that intestinal-specific tryptophan serotonin serotonin-1 (Tph-1), an enzyme molecule that is catalyzed as a substrate to produce 5-serotonin, leads to a high bone mass phenometerAlthough intestinal-derived serotonin has multiple functions in a variety of biological phenomena, the molecular mechanism serotonin production has not been fully explored the intestinal state's perception of mechanical forces is essential for maintaining normal creep, but its molecular mechanism is not clear Recent studies have revealed a mechanically sensitive Piezo1 cation channel, which is expressed in various tissues and is essential for mechanical conduction in vascular development, red blood cell volume control, and blood pressure steady state Although Piezo1 is important in mechanical perception, its function in the gut remains to be explored in this study, the NIPS team demonstrated that microbiome-derived single-stranded RNA (ssRNAs) can induce the production of serotonin in intestinal enterophilia cells without mechanical force The absence of intestinal epithelial specificity of Piezo1 can lead to impaired intestinal peristaltic, mild manifestations of experimental colitis, increased bone mass, and low levels of serotonin The researchers further found that mouse fecal extract contained large amounts of RNA, while purified fecal RNA activated Piezo1 Surprisingly, a ssRNA degradation enzyme, RNase A, eliminated the ligand activity of fecal RNA and successfully suppressed serotonin levels and increased bone volume by infusion colon These findings suggest that targeting intestinal ssRNA may be a potential strategy for regulating intestinal-derived serotonin (Biovalley Bioon.com) source: Gut Piezo1 regulates gut and bone homeostasis via RNA original source: Erika Sugisawa et al.
RNA Sensing by Gut Piezo1 Is Systemic for Serotonin Synthesis , Cell (2020) DOI: 10.1016/j.cell.2020.06.022