CELL: Overactivation of mitochondria leads to social behavioural disorders
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Last Update: 2020-05-30
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Source: Internet
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Author: User
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Social disorders are often associated with mitochondrial dysfunction and neurotransmitter changesWhile mitochondrial function is essential for brain balance, it remains to be seen whether damage to mitochondrial function can lead to social behavioural disordersrecently, researchers have shown that the homogenous gene of CYFIP1 in humans has a mutated fruit fly, a gene associated with autism and schizophrenia, that shows overactivation of mitochondria and changes in group behaviorin addition, the researchers identified the regulation of mitochondrial activity in GABA availability as a biological lying mechanism behind it and demonstrated its contribution to social behaviorSpecifically, increased mitochondrial activity can lead to the storage of gamma-aminobutyric acid (GABA) in the mitochondria, reducing GABA-energy signaling, leading to social disordersmitochondrial activity or GABA signal transduction of drugs and gene manipulation to correct observed abnormalitiesThe researchers also determined that Aralar is a mitochondrial transporter that causes GABA hold to occur when in-line granulocyte activity increasesthis study adds to our understanding of how mitochondria regulate neuronal balance and social behavior under physiological and pathological conditions
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