CELL: Neural path paths leading to hedonic overempeding and obesity have been revealed.

The survival of animals depends on the neural mechanisms that motivate behavior to meet the basic needs of the body.
, motivational behavior can be broken down into three stages.
(foraging) phase includes seeking and obtaining desired results, usually due to the accumulation of physiological needs.
this stage is followed by the consumption phase, including the feeling, exercise, and reward processes associated with achieving behavioral goals (e.g., eating food or drinking water).
satiety develops during the consumption phase and eventually terminates behavior, which may be mediated by PBNCGRP neurons.
mechanisms that shed light on these motivational behaviors need to monitor neuron dynamics to determine the neuron's selectivity in the preparation, consumption, or satiety periods.
have different goals for hunger and thirst, but control similar feeding behaviors, and so far little is known about the neural processes shared between these behavioral states.
recently, researchers identified glutamate-energy neurons (periLCVGLUT2 neurons) around the brain as a multi-synact aggregation node from independent groups of energy- and hydrated-sensitive cells.
researchers developed a stable method of post-brain calcium imaging in free-moving mice, and found that periLCVGLUT2 neurons can be adjusted for feeding behavior and react similarly to food or water consumption.
periLCVGLUT2 neurons are moderately and steady-state in the consumption process and need to be inhibited scalablely.
inhibition of neurons around LPVGLUT2 is rewarding and increases consumption by enhancing tasteability and prolonging ingestion duration.
these characteristics form a double negative feedback relationship that maintains food or water consumption without affecting food or water.
therefore, the study shows that PeriLCVGLUT2 neurons are a common hub for mediated hunger and thirst, specifically controlling food and water intake motivations, which are a factor in hedonic overeat and obesity.
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