CELL: Metabolically driven epithelial group leads to fatal infant ventricular membrane tumors
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Last Update: 2020-05-29
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Source: Internet
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Author: User
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Post-cranial (PFA) ventricular membrane tumor is a fatal malignant tumor in the infant's back brainPFA infant ventricular membrane tumors are considered epigenetic-driven tumors due to the lack of highly recurrent somatic cell mutations, but the disease now lacks a model systemrecently, researchers found that PFA ventricular membrane tumors are maintained with hypoxia and are associated with limited access to specific metabolites to reduce histone methylation and increase the demethylation and acetylation at histone 3 lysine 27 (H3K27)PFA ventricular membrane tumors are initiated in the cell line for the first three months of human development, when the fetus lives in restricted oxygenunlike other ventricular membrane tumors, the instantaneous exposure of PFA cells to ambient oxygen can cause irreversible cytotoxicityPFA tumors show lower base levels of H3K27me3, and paradoxically, inhibiting H3K27 methylation specifically disrupts the growth of PFA tumorstherefore, targeted metabolism and/or epigenomes provide a unique opportunity for reasonable treatment for patients with PFA ventricular membrane tumors
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