Cell Metab: What brain cells cause our dependence on sugar?
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Last Update: 2020-07-17
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Source: Internet
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Author: User
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!---- fibroblast growth factor 21 (FGF21) is an endocrine hormone produced by the liver that regulates nutritional and metabolic balancethe production of FGF21 increases in the context of macronutrient imbalances and sends signals to the brain to suppress sugar intake and sweetness preferences, however, so far, we have been unclear about the central targets that mediate these effectsrecently, researchers identified the target cells of FGF21 in the hypothalamus and revealed that the signaling of FGF21 to glutamate neurons is a necessary and sufficient condition for mediated FGF21-induced sugar suppression and sweetness preferences, the researchers found that FGF21 acts directly on the hypothalamus (VMH) in the inner part of the abdomen, specifically regulating sucrose intake, rather than non-nutritional sweetness preferences, weight or energy consumptionfinally, the study data showed that FGF21 affects neuronal activity by increasing neuronactivation and excitability in VMHtherefore, FGF21 signals glutamate energy neurons in VMH as an important part of the neural circuit that regulates sucrose intake.
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