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Cell Metab: Creatine promotes tumor metastasis by activating Smad2/3

 Last Update: 2021-04-13
 Source: Internet
 Author: User

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Metastasis is the main cause of cancer-related deaths, accounting for approximately 90% of cancer-related deaths.

Colorectal cancer diagnosis and management

Creatine is one of the most popular nutritional supplements and has been widely used to enhance muscle mass and function in healthy people, especially for athletes and bodybuilders.

Recently, researchers reported the adverse effects of creatine using an orthotopic mouse model, showing that creatine can promote the metastasis of colorectal cancer and breast cancer , and shorten the survival time of mice .

Creatine can promote the metastasis of colorectal cancer and breast cancer , shorten the survival period of mice.

Creatine promotes tumor metastasis by activating Smad2/3

Creatine promotes tumor metastasis by activating Smad2/3 Creatine promotes tumor metastasis by activating Smad2/3

Knockout of GATM or inhibition of MPS1 inhibits cancer metastasis by down-regulating Snail and Slug, which is conducive to the survival of mice.

Therefore, the results of the study call for caution when using dietary creatine to improve muscle mass or treat diseases, and suggest that targeting GATM or MPS1 can prevent cancer metastasis , especially for transforming growth factor beta receptor mutant colorectal cancer.

Targeting GATM or MPS1 can prevent cancer metastasisTargeting GATM or MPS1 can prevent cancer metastasis

Original source:

Liwen Zhang et al.

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