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Alzheimer's sign is gradually becoming known to the public as a degenerative disease of the central nervous system in pre-senility and old age
In the adult brain, neural stem cells that exist in the niche of the hippocampus nerve source maintain the function of nerve production for life
On May 24, 2021, Evgenia Salta of the Netherlands Institute of Neuroscience, Bart De Strooper of the University of Leuven, Belgium, and other researchers jointly published an online publication titled "Restoring miR-132 expression rescues adult hippocampal" in the international academic journal "Cell-Stem Cell" Neurogenesis and memory deficits in Alzheimer's disease" article, the article shows that restoring the expression of miR-132 can rescue adult hippocampal neurogenesis and memory deficits in Alzheimer's disease
First, the researchers performed postmortem immunohistochemical analysis on the neuronal progenitor cells proliferating in the subgranular region of the dentate gyrus of the hippocampus in tissue sections of 10 non-dementia control individuals and 10 Alzheimer's disease patients, which confirmed that they are in AD Mid-adult neurogenesis was pathologically damaged, and it was confirmed in a mouse model that the brain pathological damage in AD was related to the level of miR-132 in the adult hippocampal neurogenic niche
Next, the researchers evaluated the positioning of miR-132 in the adult neurogenic niche, and confirmed that miR-132 can be recruited by adult neural stem cells and progenitor cells as part of the response to exercise or aging-related stimuli through fluorescence sorting technology.
Finally, the researchers explored whether increasing the level of miR-132 can improve the AHN deficiency observed in Alzheimer’s disease mouse models.
In conclusion, this article confirms that miR-132 is one of the most consistently down-regulated miRNAs in AD, an effective regulator of AHN, and plays a role in cell-autonomous pre-neurogenesis in adult neural stem cells and their progeny
The findings confirm the significance of AHN in a mouse model of Alzheimer's disease and reveal the possible therapeutic potential of targeting miR-132 in neurodegeneration
Reference materials:
Reference materials:[1]https://
[1]https://
