Cell Journal: How do gut microbes after a ketogenic diet affect the brain?

In experiments on mice, the researchers found that gut microbes exacerbate the effects of cognitive impairment because they affect the hippocampus in the brain, which is essential for memory and learning

Scientists also found that ketogenic diet, hypoxia, and treatment with a dilobite called Bilophila wadsworthia can damage the hippocampus of mice and cause cognitive decline

The research was published in the journal Cell Host & Microbe

The researchers provided several mice with a ketogenic diet and other mice with a standard diet

Next, the scientists observed their ability to navigate the maze

The researchers also assessed whether different diets would cause changes in the cognitive behavior of mice without hypoxia

"These results emphasize the ability of different environmental factors to work together to affect the cognitive behavior of mice," said the study's lead author, UCLA graduate student Christine Olson (Christine Olson)

Next, the researchers investigated what would happen if the mice's microbiota were depleted before the mice were given a ketogenic diet and hypoxia

Olsen said: "This suggests that microorganisms related to ketogenic diets and hypoxia may have harmful effects on cognitive impairment

The researchers found that the genes that are turned on or off in the hippocampus have changed, and this bacterium reduces normal cell signals in the hippocampus

Olsen said: "The way that water flies disrupt hippocampal activity and cognitive behavior is similar to how hypoxia and ketogenic diet work together

Scientists have just discovered microbial species that can affect changes in the behavior of rats and other animals

Cognitive impairment afflicts millions of elderly people over 65 and is associated with a variety of chronic metabolic, immune and neurodegenerative diseases, such as Alzheimer's disease

"Identifying early risk factors is essential for early detection and intervention of cognitive impairment

The authors also added that more research is needed to determine whether other gut microbes in addition to biliary bacteria also affect cognitive ability, and whether the microbiota affects cognitive decline in humans

Journal Reference :

1. Christine A.