CELL: Immune cells can get into the brain! It also helps cells in the brain mature.
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Last Update: 2020-07-30
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Source: Internet
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Author: User
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!---- previous studies have shown that the brain is a place with relative immune privileges.although CD4 T cells have been reported to exist in the central nervous system, whether they exist in a healthy brain is still debatable, and their function remains largely unknown.here, the researchers used imaging, single-cell and surgical combinations to identify a CD69-CD4 T cell group in mice and human brains that were different from circulating CD4 T cells.the resident cell population of the brain is derived from the central differentiation of the active circulating cells and is formed by autogen and peripheral microbiome stimulation.single-cell sequencing showed that, in the absence of mouse CD4 T cells, resident small glial cells in the brain remained between the fetus and the adult.this mature defect leads to too many immature neuronal synapses and behavioral abnormalities.these results shed light on the role of CD4 T cells in brain development and the potentially dynamic relationship between the immune system and the evolution of the nervous system..
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