-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Editor-in-charge | Xi
Irritable bowel syndrome is a common functional bowel disease characterized by abnormal bowel movements, abdominal discomfort, and bloating
.
Irritable bowel syndrome imposes a huge health burden on patients, but the current definitive and effective treatment methods are very limited, and new effective treatment strategies
are urgently needed.
There is increasing evidence linking food intolerance to the pathogenesis of irritable bowel syndrome, but the pathological mechanism by which food intolerance caused by gut microbial dysregulation progresses to gastrointestinal disease is unclear
.
Recently, a research team led by Dr Wong Kai-leung, Assistant Professor of the Division of Teaching and Research, School of Chinese Medicine, Hong Kong Baptist University, and Professor Bian Zhaoxiang, Clinical Research Professor of Chinese Medicine at Tsang Siu Tim, presented a presentation at Cell Host & Microbe Ruminococcus gnavus plays a pathogenic role in diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis, identifies a rumen overgrowth of a family of hairy spirobiaceae, It is an important factor
in the development of dysmotility of the enteric motility of diarrhea-type irritable bowel syndrome (IBS-D).
The team first studied changes in the composition of the gut microbiota and its function in stool samples from IBS-D patients and found that rumen abundance was significantly increased
in IBS-D patients.
After the rumen coccus is colonized in the intestine of germ-free mice, the gastrointestinal transit time of mice can be shortened, the colonic secretion can be increased, and the mouse can be induced to produce diarrhea-like symptoms
.
Further studies have found that rumen produces excess tryptamine and phenethylamine
by transforming essential amino acids in the diet.
Feeding normal mice tryptamine and phenethylamine can also cause diarrhea-like symptoms in mice
.
The team also elucidated the mechanism by which tryptamine and phenethylamine cause diarrhea, showing that tryptamine and phenethylamine directly activate trace amine-associated receptors (TAAR1), stimulating intestinal chromaffin cells to produce serotonin, a key neurotransmitter involved in regulating intestinal movement, thereby speeding up bowel movements and secretion
.
The team also explored the therapeutic potential of targeting TAAR1 in the treatment of IBS-D, finding that TAAR1-specific antagonists effectively alleviated diarrhea-like symptoms
in mice colonized with the fecal microbiota of IBS-D patients 。 In addition, the team also found that intervening in the diet with essential amino acid content, such as feeding a diet low in tryptophan/phenylalanine, can reduce the production of tryptopin and phenylethylamine, inhibit intestinal motility in mice, suggesting that inhibiting the microbial conversion pathway of dietary amino acids to aromatic trace amines may be a novel treatment
for IBS-D.
In summary, this study provides new insights
for irritable bowel syndrome caused by intestinal microbial dysregulation by revealing sequential events involving microbial decomposition of dietary amino acids, identifying bacterial species of amino acid metabolism, characterizing amino acid-derived microbial metabolites, and studying the molecular mechanism of action affecting intestinal motility.
Original link:
https://doi.
org/10.
1016/j.
chom.
2022.
11.
006
Platemaker: Eleven
Reprint instructions
【Non-original article】The copyright of this article belongs to the author of the article, welcome to forward and share, reprinting is prohibited without the permission of the author, the author has all legal rights, violators will be investigated
.
