Cell host microbe: enteritis is related to intestinal microbial deficiency

February 27, 2020 / Biovalley bio on / -- in the United States, there are about 1 million people suffering from ulcerative colitis, which is an incurable and unknown cause of serious colon disease A recent study by researchers at Stanford University School of medicine linked it to the loss of an intestinal microbe Dr Aida habtezion, associate professor of Gastroenterology and Hepatology, the author of the paper, said: "this study helps us better understand the disease We hope to be able to use the metabolites naturally produced by bacteria to treat enteritis " When the researchers compared two groups of patients, one with ulcerative colitis and the other with rare non-inflammatory diseases, they found that specific bacterial subsets in patients with ulcerative colitis were depleted Scientists report that these patients also lack a range of anti-inflammatory substances produced by bacteria (photo source: www Pixabay Com) the results were published in the latest cell host & Microbe magazine These findings suggest that supplementation of missing bacterial metabolites in patients with ulcerative colitis may help to restore the number of intestinal bacteria, which can effectively treat these patients as well as patients with related intestinal inflammation Stanford University is currently conducting a clinical trial to determine whether the metabolite, known as "secondary bile acid," is effective in the treatment of the disease The new study began with clinical observation "Patients with familial adenomatous polyposis (FAP), a rare genetic disease, are most likely to have colon cancer," habtezion said "To prevent this, they performed exactly the same procedure on patients with refractory ulcerative colitis." However, patients in FAP bags rarely experience lower GI inflammation than the rest of patients with ulcerative colitis in bags, she said Primary bile acids are produced in the liver, stored in the gallbladder and released into the digestive tract to help emulsify fat Most of the bile acids secreted are absorbed by the gut, and then the gut bacteria convert them to secondary bile acids through a series of enzymatic reactions Previous studies have shown that in patients with ulcerative colitis and related diseases with Crohn's disease, secondary bile acid depletion may occur, and tissue damaging inflammation may occur in the colon and small intestine Furthermore, the authors found that the microbial diversity of ulcerative colitis patients decreased In addition, the researchers showed that the abundance of a bacterial subpopulation called ruminocaceae in patients with ulcerative colitis was significantly lower than that in controls Genomic analysis of all intestinal bacteria in the participants showed that the gene expression of the enzyme used to convert primary bile acid to secondary bile acid also decreased Previous studies have shown that ruminocaceae is the main population carrying these genes The researchers showed that in three different models of colitis in mice, supplementation with cholate and deoxycholic acid reduced the infiltration of inflammatory immune cells and the levels of several inflammatory signaling proteins and chemicals in the intestine Drug treatment also reduced typical symptoms of colitis in mice, such as weight loss or colonic pathology (BIOON Com) source of information: scientists link authentic sciences to missing guide microorganisms source: sidhartha R Sinha et al Dysbiosis induced secondary bill acid defence promotions intelligent infection Cell host microbe 2020doi: https://doi.org/10.1016/j.chom.2020.01.021