Cell: For the first time in the world, the battle between the puff macrophages and bacteria is revealed in real time.

September 16, 2020 /--- In a new study, researchers from the University of Calgary in Canada have discovered how to capture "live" images of immune cells in the lungs.
the first time in the world that they have found a way to record in real time how the immune system fights bacteria that affect the lungs of mice.
the findings provide new insights into how cleaners of the immune --- the so-called --- macrophages.
, which was once thought to be stationary, have observed them working, moving through the space, between and around the vesicles in search of bacteria and viruses.
study was recently published in the journal Cell under the title "Patrolling Alveolar Macrophages Conceal Bacteria from Immune System to Maintain Homeostasis."
from Cell, 2020, doi:10.1016/j.cell.2020.08.020.
, co-author of the paper and a co-author of the paper, said, "It makes sense for macrophages to move, but we can only assume that, because we can't observe their movements."
we can do that now.
the lungs are much more than macrophages, and these tiny cleaners are very effective at protecting each one.
" the researchers say macrophages do very simple work.
imagine a hotel where there are more rooms than cleaners.
cleaners use the corridors to clean and keep things tidy.
inside the lungs, there is a corridor that provides space between the vesicles.
macrophages use this space to move around, destroying any foreign particles, including bacteria and viruses that affect the bubbles.
researchers need to overcome three major obstacles to capture real-time images of the immune cells as they function.
they need to develop an image capture method from air to liquid to air, they need to keep the lungs stable long enough to get a clear picture, they need to find a way to identify and mark the velecular macrophages.
study is the result of years of research by scientists around the world," said Arpan Neupane, lead author of the paper and a doctoral student at the University of Calgary.
we put everything together, combined and refined many imaging techniques.
even six years ago, this was impossible.
"'s ability to observe the role of macrophages also reveals something else: The researchers looked at finding that powerful alppular macrophages become paralysed and stop performing their vital tasks.
"We know that when someone is struggling with a serious infection, especially a respiratory virus like the flu virus or SARS-CoV-2, they often suffer from secondary infections, which can lead to death," Kubes said.
with this new imaging technique, they were able to observe what happened to the vesicle macrophages in the process.
" has proven that in the fight against infection, at some point, efficient macrophages become paralysed, making it easier for new infections to gain a foothold and grow.
the next step in our study is to find out why this is happening, so we can develop targeted therapies that start macrophages to work again," Kubes said.
" (bioon.com) Reference: 1. Arpan Sharma Neupane et al. Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis. Cell, 2020, doi:10.1016/j.cell.2020.08.020.2.Researchers discover how to capture images of cells work at inside our lungs.