Cell Discov: Seaweed extract is more effective at suppressing SARS-CoV-2 than Redsewe!

!--webeditor:page title"--July 27, 2020 -- In tests of the antiviral effects of the virus that causes COVID-19, a substance derived from the consumption of seaweed greatly exceeds the current standard antiviral drug used to fight the disease, RedsiweHeparin is a common blood thinner, a heparin variant that loses anticoagulant properties and plays the same role as Redseyvir in suppressing SARS-CoV-2 infection in mammalian cellsThe study, recently published on the Cell Discovery website, is the latest example of baiting tacticsResearchers from the Centre for Biotechnology and Interdisciplinary Studies (CBIS) at the Rensselaer Institute of Technology are developing a new strategy for a new coronavirus that has triggered the current global health crisisThe study was entitled "Sulfated polysaccharides effectively AR-CoV-2 in vitro"The stingprotein on the surface of SARS-CoV-2 binds to an ACE-2 receptor on the surface of human cellsOnce combined, the virus inserts its own genetic material into the cell, hijacking the cell machine to create a copy of the virusBut viruses can also be easily persuaded to lock a bait molecule that provides a similar matchThe neutralized virus is captured and eventually degrades naturallyPhoto Source: Previous research by Cell Discovery has shown that this trick can trap other viruses, including dengue, Zika and influenza A"We're learning how to stop viral infections, and if we want to respond quickly to a pandemic, we're going to need that knowledge," said Jonathan Dordick, lead researcher on the study and professor of chemistry and bioengineering at the Lensler Institute of Technology"The reality is that we don't have good antiviral drugsTo protect ourselves from future pandemics, we will need a series of ways to quickly adapt to emerging virusesCell Discovery's paper tested the antiviral activity of three different heparins (heparin, triamcinolone and a non-anticoagulant low molecular weight heparin) and two brown algae polysaccharides (RPI-27 and RPI-28) extracted from seaweedAll five compounds are long-chain sugar molecules called sulfate polysaccharidesA combined study published earlier this month in Antiviral Research found that this structural structure is an effective baitThe researchers performed a dose response study on mammalian cells, called EC50 (an acronym for the effective concentration of the compound that inhibits 50% viral infection) For EC50 results, this is given at molar concentration, a lower value that marks a more potent compound The EC50 value of the RPI-27 is about 83 namoles, compared with 770 namoles previously published in independent in vitro trials on the same mammalian cell Heparin's EC50 is 2.1 micromoles, about one-third of Redsewere activity, and the non-anticoagulant analogue of heparin, EC50, is 5.0 micromoles, about one-fifth of Redsewere activity Another test found that no cytotoxicity was found in any of the compounds, even at the highest concentrations "What we're interested in is a new approach to infection," said Robert Linhardt, a professor of chemical and chemical biology at Renssler who is working with Dordick on a trick strategy "The idea is that COVID-19 infection begins in the nose, and either of these substances can form the basis of nasal sprays If you can simply treat the infection early, even before it is done, you can stop it before it enters the body Dordick added that compounds extracted from seaweed "can serve as a basis for oral administration to address potential gastrointestinal infections." "In the study of SARS-CoV-2 sequencing data, Dordick and Linhardt found several base sequences on the structure of the stingprotein, which are expected to match heparin, and the results were confirmed in the combined study This stingprotein is encased in a large amount of polysaccharides, an adaptation that protects it from the degradation of human enzymes and is ready to bind to specific receptors on the cell surface Photo Source: Cell Discovery Dordick: "It's a very complex mechanism, and frankly, we don't know all the details, but we're getting more information." What is clear in this study is that the larger the molecule, the more suitable it is The more successful compound is the larger sulfate polysaccharides, which provide more location for the molecule to capture the virus "Molecular models based on combined studies reveal sites where heparin can interact on stingproteins, improving the prospect of applications similar to polysaccharides of sulphuric acid "This exciting study by Professor Dordick and Professor Linhardt is one of several ongoing studies by CBIS and Rensselaer to address the challenges of the covid19 pandemic through new treatments and the reuse of existing drugs," said Deepak Vashishhth, director of CBIS References: Paul S Kwon et al Sulfated polysaccharides effectively ar-sars-CoV-2 in vitro, Cell Discovery (2020) DOI: 10.1038/s41421-020-00192-8In cell studies, seaweed outperforms remdesivir in blocking COVID-19 virusSo Young Kim et al, spechese heparin and acute sing-sing-sac-sac-sac-sin-savirus 2 DOI: 10.1016/j.antiviral.2020.104873 !--/webeditor:!--:page:title""""-Common-approved-drug-e-mayly-neutralize-the-director-co-dis-!---!---.