Cell Death Dis: Tumor-related fibroblasts can affect the circadian rhythms of colon cancer cells

The biological clock regulates the expression level of proteins and their functional characteristics, such as the rhythms associated with cell growth, which regulate the overall activity of cells in a steady state and tissueprevious studies have found that circadian rhythm disorders may be a potential cause of cancer, suggesting that normal circadian rhythms may have potential anti-tumor effectsHowever, the correlation between abnormal cellular circadian rhythms and significantly increased cancer risk, as well as their potential mechanisms, remain to be studiedthe modification of the tumor microenvironment by the cancer cells can enhance the development of tumor and remove the corresponding tumor suppressorsThe researchers found that the colon cancer cell strain HCT116, which was cultured with HCT116 cells in combination with HCT116 cells, affected the physiological rhythm and protein expression level associated with HCT116 cell growth and weakened the proliferation cycle of HCT116 cells, suggesting that TAF may have lost or obtained certain physiological and arrhythmia inhibitorsthrough analysis of fibroblastside secretion factors, the researchers found that IL6 can reduce the growth oscillation cycle of HCT116 cells, inhibit early cell proliferation, and raise scoresEarly expression levels of markers CEA and CDX2 and reduced phosphorylation levels of early ERK5in summary, the study's data suggest that tumor-related fibroblasts can affect the physiological rhythms of surrounding cancer cells, and THAT IL6 may be a new target for preoperative therapy