Cell Death Dis: LncRNA KCNQ1OT1 Promotes Osteosarcoma Progress by Enhancing Aerobic Sugar Enzymes

Ostoma (OS) is one of the most invasive and common primary malignant bone tumors, most common in children and adolescentsWith the progress of various treatments, such as surgery, chemotherapy and radiotherapy, the five-year survival rate for non-metastatic OS patients has reached 60 per centHowever, the total survival rate of OS has not increased significantly in the past decade due to little knowledge of the pathogenesis of OS and related molecular mechanismstherefore, exploring the molecular mechanisms associated with OS development and pathogenesis and identifying more effective therapeutic targets are critical to further improving the prognosis of OS patients in the clinicmetabolic conversion (also known as the Warburg effect) from oxidation phosphorylation to aerobic sugar enzyme solutions is a hallmark of osteosarcoma(OS), a process that enhances the cell's chemotherapy resistance, growth, metastasis, and aggressionnew research shows that long-chain uncoded RNA (lncRNA) plays a crucial role in the Warburg effect of cancer cellsin the study, the researchers found that lncRNA KCNQ1OT1 had an increase in expression levels in THE OSAt the same time, functional experiments have found that KCNQ1OT1 can promote the proliferation of OS cells and inhibit their apoptosisIn addition, KCNQ1OT1 promotes the Warburg effect by stimulating the expression of ALDOA (altidase A)in addition, bioinformatics analysis, luciferase reporting gene experiments, RNA immunoprecipitation and RNA pull-down experiments have found that KCNQ1OT1 can act as a molecular sponge of miR-34c-5p as a competitive endogenous RNA (ceRNA), while miR-34c-5p can be directly targeted at the 3'UTR region of ALDOA to suppress their expression, the study shows that KCNQ1OT1 plays a key role in the reprogramming of glucose metabolism in osteosarcomaThe KCNQ1OT1/miR-34c-5p/ALDOA pathway may be a potential therapeutic target for osteosarcoma