Cell Death Differ:FBXO32: Key factors associated with ubibinization in melanoma cells and oscic genetic remodeling

As a post-translation modification, ubibination can degrade the target protein through subsequent protease or lysosome pathways and play a vital role in the steady state of the protein.
can not only act as the main degradation signal of protein, but also regulate protein interaction, function and positioning.
previous studies have shown that ubibinization regulates a wide range of cellular processes, including NF-B pathway activity, DNA damage repair, cell death, cell autophagy, and metabolism.
and ubibinic disorders can also lead to a variety of pathological reactions, including cancer.
, it is important to study the cellular processes of ubiquitin-related gene regulation and ubiquitin regulation to raise awareness of related diseases.
skin melanoma originated in melanin cells, a cell derived from a nerve crucible that produces skin pigment.
, as the most aggressive form of skin cancer, has a very high metastatic capacity.
metastatic melanoma is the main cause of skin cancer-related deaths.
study, which also found that FBXO32 regulates the migration of melanoma cells, researchers found that MITF, the main transcription factor in melanoma cells, regulates ubibinization in melanoma cells.
researchers identified FBXO32, a component of the SCF E3 connective enzyme complex, as a new target gene for MITF.
studies have shown that FBXO32 promotes the migration, proliferation, and development of melanoma cells.
of the transcription group showed that knocking down FBXO32 induced an overall change in the melanoma gene expression spectrum.
and silent FBXO32 inhibit CDK6 and inhibit cell proliferation and aggression.
FBXO32 is associated with chromatin remodeling complexes at regulatory points, proteomics analysis identifies SMARC4 (the component of chromatin remodeling complex BAF/PBAF) as the molecular partner of FBXO32.
researchers found that FBXO32 and SMARCA4 were located on the gene base of FBXO32 regulation (e.g. CDK6), indicating that FBXO32 regulates the transcription of related genes by regulating the activity of chromatin remodeling complexes.
in summary, the study provided a comprehensive analysis of the role of FBXO32 in melanoma, which regulates key biological processes and gene transcription of melanoma cells through an oscic genetic approach.